Yushchuk Anna, Pykaliuk Vasyl, Korzhyk Olha
Clinical and Diagnostic Laboratory of the Municipal Enterprise Volyn Regional Infectious Diseases Hospital of the Volyn Regional Council, Faculty of Medicine Lesya Ukrainka Volyn National University Lutsk Ukraine.
Department of Human Anatomy, Faculty of Medicine Lesya Ukrainka Volyn National University Lutsk Ukraine.
Health Sci Rep. 2023 Jul 5;6(7):e1403. doi: 10.1002/hsr2.1403. eCollection 2023 Jul.
The main objective of this study is to establish the characteristics of blood laboratory parameters in hospitalized coronavirus disease 2019 (COVID-19) Ukrainian patients and the significance of the above-mentioned parameters for predicting the course of the disease.
Hematocytological, biochemical, and hemostasis methods of research have been used. Groups of patients with different forms of the coronavirus disease course have been analyzed (lethality - recovery, recovery with a severe and mild course).
Age is one of the risk factors for COVID-19 mortality. Absolute values of neutrophils, neutrophil-lymphocyte ratio (NLR), systemic inflammation index, d-dimer, C-reactive protein, and soluble fibrin complex can be used by clinicians to effectively differentiate between two possible outcomes (lethality vs. recovery). A higher number of stab leukocytes, d-NLR, and platelets concentration have been recorded in patients with severe COVID-19 cases, compared to mild ones. The risk of adverse COVID-19 outcome (lethality) is significantly linked with d-dimer and NLR (odds ratio 1.42). The risk of a severe course of the disease was significantly associated with the count of leukocytes (odds ratio 4.96).
本研究的主要目的是确定乌克兰住院的2019冠状病毒病（COVID-19）患者血液实验室参数的特征，以及上述参数对预测疾病进程的意义。
采用血液细胞学、生化和止血研究方法。对不同病程形式的冠状病毒病患者组进行了分析（致死 - 康复、重症和轻症康复）。
年龄是COVID-19死亡的危险因素之一。临床医生可利用中性粒细胞绝对值、中性粒细胞与淋巴细胞比值（NLR）、全身炎症指数、D-二聚体、C反应蛋白和可溶性纤维蛋白复合物，有效区分两种可能的结果（致死与康复）。与轻症COVID-19患者相比，重症患者的杆状白细胞数量、d-NLR和血小板浓度更高。COVID-19不良结局（致死）风险与D-二聚体和NLR显著相关（优势比1.42）。疾病重症进程风险与白细胞计数显著相关（优势比4.96）。
