Department of Gastroenterology, Abant Izzet Baysal University Hospital, Bolu, Turkey.
Eur J Gastroenterol Hepatol. 2022 Mar 1;34(3):324-327. doi: 10.1097/MEG.0000000000002219.
Chronic hepatitis B is associated with important morbidity and mortality. Inflammation has a pivotal role in hepatic fibrosis of this population. Hemogram-derived inflammatory predictors, such as mean platelet volume (MPV) and platelet to lymphocyte ratio (PLR), are supposed as inflammatory markers in various diseases. We aimed to compare MPV and PLR of the patients with chronic hepatitis B to those of healthy controls and to observe possible correlation between these markers and fibrosis.
Chronic hepatitis B patients that visited our outpatient gastroenterology clinics were enrolled in the study. Healthy volunteers were enrolled as controls. MPV, PLR and other parameters of the study groups were compared.
Median MPV of the mild fibrosis, advanced fibrosis control groups were 8.1 (6.6-13) fL, 8.2 (6.3-14.5) fL and 7.2 (4.6-8.9) fL, respectively (P < 0.001). Median PLR of the mild fibrosis, advanced fibrosis control groups were 99.5 (36-259) %, 119 (61-1547) % and 122 (64-197) %, respectively (P = 0.02). PLR was correlated with the ISHAK score (r = 0.32, P = 0.002). A MPV value greater than 7.52 fL have 80% sensitivity and 56% specificity in determining advanced fibrosis (AUC: 0.68, P = 0.002, 95% confidence interval, 0.58-0.77).
We think that increased MPV and decreased PLR are characteristics of chronic hepatitis B disease. Moreover, increased MPV could predict advanced fibrosis in this population.
慢性乙型肝炎与重要的发病率和死亡率相关。炎症在该人群的肝纤维化中起着关键作用。血液学衍生的炎症预测因子，如平均血小板体积（MPV）和血小板与淋巴细胞比值（PLR），被认为是各种疾病的炎症标志物。我们旨在比较慢性乙型肝炎患者与健康对照组的 MPV 和 PLR，并观察这些标志物与纤维化之间的可能相关性。
我们招募了就诊于我院门诊消化科的慢性乙型肝炎患者作为研究对象，并招募了健康志愿者作为对照组。比较了研究组的 MPV、PLR 和其他参数。
轻度纤维化、进展性纤维化对照组的中位数 MPV 分别为 8.1（6.6-13）fL、8.2（6.3-14.5）fL 和 7.2（4.6-8.9）fL（P<0.001）。轻度纤维化、进展性纤维化对照组的中位数 PLR 分别为 99.5（36-259）%、119（61-1547）%和 122（64-197）%（P=0.02）。PLR 与 ISHAK 评分相关（r=0.32，P=0.002）。MPV 值大于 7.52 fL 时，对诊断进展性纤维化的敏感性为 80%，特异性为 56%（AUC：0.68，P=0.002，95%置信区间，0.58-0.77）。
我们认为，MPV 增加和 PLR 降低是慢性乙型肝炎的特征。此外，MPV 增加可预测该人群的进展性纤维化。
Zotero 插件