Department of Imaging, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China.
MR Scientific Marketing, Siemens Healthineers, Shanghai 201318, China.
J Interv Cardiol. 2023 Jun 28;2023:4611602. doi: 10.1155/2023/4611602. eCollection 2023.
To evaluate the value of the cardiac magnetic resonance intravoxel incoherent motion (IVIM) technique in microcirculatory dysfunction in patients with hypertrophic cardiomyopathy (HCM).
The medical records of 19 patients with HCM in our hospital from January 2020 to May 2021 were collected retrospectively, and 23 healthy people with a similar age and gender distribution to the patients with HCM were included as controls. All the included subjects underwent clinical assessment and cardiac magnetic resonance imaging. The original IVIM images were analysed, and the imaging parameters of each segment were measured. The HCM group was divided into non-hypertrophic myocardium and hypertrophic myocardium groups. The differences in imaging parameters between the normal and HCM groups were compared. A Spearman correlation analysis was used to explore the correlation between end-diastolic thickness (EDTH) and each IVIM parameter.
The D and f values in the HCM group were lower than those in the normal group ( < 0.0001 and = 0.004, respectively). The f, D, D, and EDTH values of the hypertrophic segment, non-hypertrophic segment, and normal groups were statistically significant ( < 0.05). The difference in D values among the mild, moderate, severe, and very severe HCM groups was statistically significant ( < 0.05). There was a statistically significant difference in EDTH among the mild, moderate, severe, and very severe groups ( < 0.001). There were significant differences in the values of D, D, and f between the non-delayed enhancement group and the delayed enhancement group ( < 0.05). The EDTH values of 304 segments in the HCM group were negatively correlated with f ( = -0.219, = 0.028) and D values ( = -0.310, < 0.001).
The use of IVIM technology can achieve a non-invasive early quantitative assessment of microvascular disease in HCM without the injection of a contrast agent and provide a reference for the early diagnosis of and intervention in myocardial ischemia in patients with HCM.
评估心脏磁共振体素内不相干运动（IVIM）技术在肥厚型心肌病（HCM）患者微循环功能障碍中的价值。
回顾性收集 2020 年 1 月至 2021 年 5 月我院 19 例 HCM 患者的病历资料，纳入与 HCM 患者年龄和性别分布相匹配的 23 例健康人作为对照组。所有纳入对象均进行临床评估和心脏磁共振成像检查。对原始 IVIM 图像进行分析，并测量各节段的成像参数。将 HCM 组分为非肥厚心肌组和肥厚心肌组，比较正常组和 HCM 组的影像学参数差异。采用 Spearman 相关分析探讨舒张末期厚度（EDTH）与各 IVIM 参数的相关性。
HCM 组的 D 值和 f 值均低于正常组（均<0.0001， = 0.004）。肥厚节段、非肥厚节段和正常组的 f、D、D和 EDTH 值比较差异均有统计学意义（均<0.05）。HCM 组轻度、中度、重度和极重度组间 D 值比较差异均有统计学意义（均<0.05）。HCM 组的 EDTH 值在轻度、中度、重度和极重度组间比较差异均有统计学意义（均<0.001）。非延迟强化组与延迟强化组的 D、D和 f 值比较差异均有统计学意义（均<0.05）。HCM 组 304 个节段的 EDTH 值与 f 值（ = -0.219， = 0.028）和 D 值（ = -0.310， < 0.001）呈负相关。
使用 IVIM 技术无需注射造影剂即可实现对 HCM 微血管疾病的无创早期定量评估，为 HCM 患者心肌缺血的早期诊断和干预提供参考。
