Grill H J, Schulkin J, Flynn F W
Behav Neurosci. 1986 Aug;100(4):536-43. doi: 10.1037//0735-7044.100.4.536.
Physiological and behavioral concomitants of sodium need were studied in supracollicularly transected and pair-fed intact rats. Chronic decerebrate rats, like intact rats, reduced their urine sodium output when placed on a sodium-deficient diet. Similarly, 24 hr after sodium loading, decerebrate and intact rats excreted comparable levels of the excess sodium. In the 2 hr immediately following the loading, decerebrate rats excreted less sodium. In contrast, behavioral aspects of sodium homeostasis were completely absent in chronic decerebrate rats. In separate experiments, intraoral intake, and taste-reactivity responses, elicited by intraoral infusions of NaCl were measured during sodium-replete and sodium-deficient conditions. In response to oral infusions of NaCl, intact rats consumed significantly more and produced greater numbers of ingestive taste-reactivity responses when they were sodium deficient than when they were sodium replete. The same sodium-depletion treatments in chronic decerebrate rats, however, altered neither the intraoral intake of NaCl nor the frequency of NaCl-elicited ingestive taste-reactivity responses. These results suggest that the behavioral compensatory responses that follow changes in the internal sodium state are dependent upon forebrain mechanisms.
在大脑上丘横断和配对喂养的完整大鼠中研究了钠需求的生理和行为伴随现象。慢性去大脑大鼠与完整大鼠一样，在给予缺钠饮食时会减少尿钠排出量。同样，在钠负荷后24小时，去大脑大鼠和完整大鼠排出的过量钠水平相当。在负荷后的 immediately 2小时内，去大脑大鼠排出的钠较少。相比之下，慢性去大脑大鼠完全没有钠稳态的行为方面。在单独的实验中，在钠充足和缺钠条件下测量了经口内注入氯化钠引发的经口摄入量和味觉反应。对经口注入氯化钠的反应，完整大鼠在缺钠时比钠充足时摄入更多且产生更多的摄食性味觉反应。然而，慢性去大脑大鼠的相同缺钠处理既未改变经口摄入氯化钠的量，也未改变由氯化钠引发的摄食性味觉反应的频率。这些结果表明，内部钠状态变化后的行为补偿反应依赖于前脑机制。
