Pluimer Brock R, Harrison Devin L, Boonyavairoje Chanon, Prinssen Eric P, Rogers-Evans Mark, Peterson Randall T, Thyme Summer B, Nath Anjali K
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
iScience. 2023 Jun 14;26(7):107099. doi: 10.1016/j.isci.2023.107099. eCollection 2023 Jul 21.
is a genetic risk factor for multiple psychiatric disorders. Compared to the dozens of murine models, there is a paucity of zebrafish models-an organism amenable to high-throughput experimentation. We conducted the longitudinal neurobehavioral analysis of mutant zebrafish across key stages of life. During early developmental stages, mutants exhibited abrogated behavioral responses to sensory stimuli across multiple testing platforms. Moreover, during exposure to an acoustic sensory stimulus, loss of resulted in the abnormal activation of neurons in the pallium, cerebellum, and tectum-anatomical sites involved in the integration of sensory perception and motor control. In adulthood, mutants exhibited sexually dimorphic reduction in anxiogenic behavior in novel paradigms. Together, these findings implicate in sensorimotor processes and the genesis of anxiogenic behaviors, which could be exploited for the development of novel treatments in addition to investigating the biology of sensorimotor transformation in the context of deletion.
是多种精神疾病的遗传风险因素。与数十种小鼠模型相比，斑马鱼模型较少，而斑马鱼是一种适合高通量实验的生物。我们对突变斑马鱼在生命的关键阶段进行了纵向神经行为分析。在早期发育阶段，突变体在多个测试平台上对感觉刺激的行为反应被消除。此外，在暴露于听觉感觉刺激期间，的缺失导致在大脑皮层、小脑和顶盖（参与感觉感知和运动控制整合的解剖部位）中的神经元异常激活。在成年期，突变体在新范式中表现出焦虑行为的性别差异减少。总之，这些发现表明在感觉运动过程和焦虑行为的发生中起作用，这除了在缺失的背景下研究感觉运动转换的生物学外，还可用于开发新的治疗方法。
