The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China.
Tumor Virus RNA Biology Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA.
Int J Biol Sci. 2023 Jun 12;19(10):3057-3076. doi: 10.7150/ijbs.83368. eCollection 2023.
Serine/arginine rich splicing factor 3 (SRSF3) is an important multi-functional splicing factor, and has attracted increasing attentions in the past thirty years. The importance of SRSF3 is evidenced by its impressively conserved protein sequences in all animals and alternative exon 4 which represents an autoregulatory mechanism to maintain its proper cellular expression level. New functions of SRSF3 have been continuously discovered recently, especially its oncogenic function. SRSF3 plays essential roles in many cellular processes by regulating almost all aspects of RNA biogenesis and processing of many target genes, and thus, contributes to tumorigenesis when overexpressed or disregulated. This review updates and highlights the gene, mRNA, and protein structure of SRSF3, the regulatory mechanisms of SRSF3 expression, and the characteristics of SRSF3 targets and binding sequences that contribute to SRSF3's diverse molecular and cellular functions in tumorigenesis and human diseases.
丝氨酸/精氨酸丰富剪接因子 3（SRSF3）是一种重要的多功能剪接因子，在过去三十年中引起了越来越多的关注。SRSF3 的重要性体现在其在所有动物中高度保守的蛋白质序列和代表自我调节机制以维持其适当细胞表达水平的可选外显子 4。最近，SRSF3 的新功能不断被发现，特别是其致癌功能。SRSF3 通过调节许多靶基因的 RNA 生物发生和加工的几乎所有方面，在许多细胞过程中发挥着重要作用，因此，当过度表达或失调时，会促进肿瘤发生。本综述更新并强调了 SRSF3 的基因、mRNA 和蛋白质结构、SRSF3 表达的调节机制以及 SRSF3 靶标和结合序列的特征，这些特征有助于 SRSF3 在肿瘤发生和人类疾病中的多种分子和细胞功能。
