HO 驱动的三级 C-H 键的酶促氧化官能化。

HO-driven enzymatic oxyfunctionalization of tertiary C-H bonds.

机构信息

University of Chinese Academy of Sciences, Beijing 100049, China.

Key Laboratory of Engineering Biology for Low-carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 West 7th Avenue, Tianjin 300308, China.

出版信息

Chem Commun (Camb). 2023 Jul 25;59(60):9219-9222. doi: 10.1039/d3cc02925e.

DOI:10.1039/d3cc02925e

PMID:37416971

Abstract

Peroxygenase from catalyses the selective hydroxylation of tertiary C-H bonds, whereby tertiary alcohols, diols, ketols, ., were obtained in good to high regioselectivity and turnover numbers. This method can also be expanded for late-stage functionalization of drug molecules, which represents a streamlined synthetic method to give access to useful compounds.

摘要

过氧化物酶从催化选择性的叔 C-H 键羟化，由此得到的叔醇、二醇、酮醇等具有良好到高的区域选择性和周转数。该方法也可扩展用于药物分子的后期功能化，这代表了一种简化的合成方法，可以获得有用的化合物。