Department of Orbit, Oculoplasty, Ocular Oncology and Ocular Prosthesis, Aravind Eye Hospital, Madurai, Tamil Nadu, India.
Ophthalmology Resident, Aravind Eye Hospital, Madurai, Tamil Nadu, India.
Indian J Ophthalmol. 2023 Jul;71(7):2906-2910. doi: 10.4103/IJO.IJO_3117_22.
Rhino-orbito-cerebral mucormycosis (ROCM) is the most commonly noted form of mucormycosis, which is the most common secondary fungal infection following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Osteomyelitis is one of the rare sequelae of ROCM, frontal osteomyelitis being the rarest. We present four patients of coronavirus disease 2019 (COVID-19)-associated mucormycosis, who presented with frontal bone osteomyelitis after being treated for ROCM surgically and medically. This is the first case series highlighting this complication in post-COVID-19 mucormycosis patients and needs utmost attention as it can be life-threatening and can cause extreme facial disfiguration. All four patients are alive with salvage of the affected globe and vision being preserved in one patient. If identified early, disfiguration of face and intracranial extension can be avoided.
鼻眶脑型毛霉菌病（ROCM）是毛霉菌病中最常见的一种，是继严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染后最常见的继发性真菌感染。骨髓炎是 ROCM 的罕见后遗症之一，而额骨骨髓炎则是最罕见的。我们报告了 4 例与 2019 年冠状病毒病（COVID-19）相关的毛霉菌病患者，他们在接受 ROCM 的手术和药物治疗后出现额骨骨髓炎。这是首例强调 COVID-19 后毛霉菌病患者出现这种并发症的病例系列，需要高度重视，因为它可能危及生命，并导致严重的面部毁容。所有 4 名患者均存活，受累眼球得以挽救，1 名患者的视力得以保留。如果早期发现，可避免面部畸形和颅内蔓延。
