Franey C, Aldhous M, Burton S, Checkley S, Arendt J
Br J Clin Pharmacol. 1986 Jul;22(1):73-9. doi: 10.1111/j.1365-2125.1986.tb02882.x.
Acute administration of the antidepressant drug desipramine (DMI) in man, increased evening melatonin secretion, which reached peak plasma levels 2-4 h earlier than after placebo administration. The increase at set time points 21.00 h-22.00 h was directly proportional to an individual's integrated night-time secretion of melatonin. We have shown that this stimulation was not an effect of DMI inhibition on the hepatic metabolism of melatonin to 6-sulphatoxy melatonin (aMT6s), indeed aMT6s is in itself a good index of the evening melatonin rise. The stimulation of early evening melatonin by DMI might be exploited as a simple pineal function test.
在人体中急性给予抗抑郁药物地昔帕明（DMI），可增加夜间褪黑素分泌，其血浆峰值水平比给予安慰剂后提前2 - 4小时出现。在21:00 - 22:00的特定时间点，其增加量与个体夜间褪黑素的综合分泌量成正比。我们已经表明，这种刺激并非DMI抑制褪黑素向6 - 硫酸氧褪黑素（aMT6s）肝代谢的结果，实际上aMT6s本身就是夜间褪黑素升高的一个良好指标。DMI对傍晚早期褪黑素的刺激作用可被用作一种简单的松果体功能测试。
