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随着年龄增长，变得不再单调乏味。

Becoming less beige with age.

机构信息

Department of Molecular & Cellular Endocrinology, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope Medical Center, Duarte, United States.

Department of Molecular & Cellular Endocrinology, Arthur Riggs Diabetes and Metabolism Research Institute and the Comprehensive Cancer Center, Beckman Research Institute, City of Hope Medical Center, Duarte, United States.

出版信息

Elife. 2023 Jul 7;12:e89700. doi: 10.7554/eLife.89700.

DOI:10.7554/eLife.89700
PMID:37417552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10328496/
Abstract

The production of beige adipocytes following cold exposure is blocked as mice get older and leads to changes in the expression of metabolic genes.

摘要

随着年龄的增长，冷暴露后米色脂肪细胞的产生被阻断，导致代谢基因表达的变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbba/10328496/6399d7a9c385/elife-89700-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbba/10328496/6399d7a9c385/elife-89700-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbba/10328496/6399d7a9c385/elife-89700-fig1.jpg

相似文献

1
Becoming less beige with age.随着年龄增长，变得不再单调乏味。
Elife. 2023 Jul 7;12:e89700. doi: 10.7554/eLife.89700.
2
[Evaluation of Naturally Occurring Compounds Regulating Brown/Beige Adipocyte Differentiation].[调节棕色/米色脂肪细胞分化的天然化合物的评估]
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本文引用的文献

1
Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming.衰老会损害冷诱导的米色脂肪生成和脂肪细胞代谢重编程。
Elife. 2024 May 22;12:RP87756. doi: 10.7554/eLife.87756.
2
Age-dependent Pdgfrβ signaling drives adipocyte progenitor dysfunction to alter the beige adipogenic niche in male mice.年龄依赖性 PDGFRβ 信号驱动脂肪细胞祖细胞功能障碍，改变雄性小鼠的米色脂肪生成龛。
Nat Commun. 2023 Mar 31;14(1):1806. doi: 10.1038/s41467-023-37386-z.
3
Post-translational control of beige fat biogenesis by PRDM16 stabilization.
PRDM16 稳定对米色脂肪生成的翻译后调控。
Nature. 2022 Sep;609(7925):151-158. doi: 10.1038/s41586-022-05067-4. Epub 2022 Aug 17.
4
Adipose-tissue plasticity in health and disease.健康与疾病中的脂肪组织可塑性。
Cell. 2022 Feb 3;185(3):419-446. doi: 10.1016/j.cell.2021.12.016.
5
Cellular Origins of Beige Fat Cells Revisited.重新审视褐色脂肪细胞的细胞起源。
Diabetes. 2019 Oct;68(10):1874-1885. doi: 10.2337/db19-0308.
6
Thermal stress induces glycolytic beige fat formation via a myogenic state.热应激通过成肌状态诱导糖酵解米色脂肪形成。
Nature. 2019 Jan;565(7738):180-185. doi: 10.1038/s41586-018-0801-z. Epub 2018 Dec 19.
7
Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and Humans.细胞衰老导致老年小鼠和人类中冷诱导米色脂肪细胞形成失败。
Cell Metab. 2017 Feb 7;25(2):481. doi: 10.1016/j.cmet.2017.01.011.
8
Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice.人类“亮/米色”脂肪细胞由毛细血管网络发育而来，将其植入可改善小鼠的代谢稳态。
Nat Med. 2016 Mar;22(3):312-8. doi: 10.1038/nm.4031. Epub 2016 Jan 25.
9
Pdgfrβ+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice.血小板衍生生长因子受体β阳性（Pdgfrβ+）壁前脂肪细胞促成成年小鼠高脂饮食喂养和长期冷暴露诱导的脂肪细胞增生。
Cell Metab. 2016 Feb 9;23(2):350-9. doi: 10.1016/j.cmet.2015.10.018. Epub 2015 Nov 25.
10
Ebf2 is a selective marker of brown and beige adipogenic precursor cells.Ebf2是棕色和米色脂肪生成前体细胞的一个选择性标志物。
Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14466-71. doi: 10.1073/pnas.1412685111. Epub 2014 Sep 2.