College of Basic Medicine, Chengdu University of Traditional, Chinese Medicine, Chengdu, Sichuan, China.
Medicine (Baltimore). 2023 Jul 7;102(27):e34310. doi: 10.1097/MD.0000000000034310.
To evaluate the efficacy and safety of traditional Chinese medicine formulas combined with acupuncture for the treatment of ovulation dysfunction infertility (ODI).
From January 1, 2018 to March 12, 2023, 7 electronic databases, PubMed, EMBASE, Web of Science, Cochrane Library, CNKI, Wanfang Database, and CBM, were systematically searched to identify eligible randomized controlled trial studies.
Meta analysis showed that traditional Chinese medicine combined with acupuncture can more effectively improve sex hormone levels compared to Western medicine alone, including follicle stimulating hormone (FSH) in older patients (standardized mean difference [SMD]: 3.00; 95% confidence interval [CI]: 2.35-3.66; P = .024, I 2 = 28%), FSH in younger patients (SMD: 0.45; 95% CI: -0.15, 1.05; P = .03, I 2 = 71%), estradiol (E2) (SMD: 7.50; 95% CI: v0.47, 15.48; P < .00001, I 2 = 99%), and progesterone (P) (SMD: 2.20; 95% CI: 2.07-2.33; P < .00001, I 2 = 29%). Compared to Western medicine alone, traditional Chinese medicine combined with acupuncture also had a better effect to increase ovulation rate (risk ratio [RR]: 2.46; 95% CI: 1.72-3.52; P < .00001, I 2 = 0%), pregnancy rate (RR: 2.50; 95% CI: 1.96-3.18; P < .00001, I 2 = 0%), maximum follicle diameter (MFD) (SMD: 2.27; 95% CI: 1.37-3.16; P < .00001, I 2 = 91%), and endometrial thickness (SMD: 1.71; 95% CI: 1.31-2.11; P < .00001, I 2 = 87%). The combination of traditional Chinese medicine and acupuncture also had better effects on quality of life (RR: 0.19; 95% CI: 0.15-0.23; P < .00001, I 2 = 0%) and reduced adverse reactions (RR: 0.15; 95% CI: 0.05-0.48; P = .001, I 2 = 0%), compared to Western medicine alone.
This study shows evidence that traditional Chinese medicine formulas combined with acupuncture are an effective and safe treatment approach. However, this conclusion requires further confirmation due to the insufficient quality of the included trials.
评估中药方剂联合针灸治疗排卵功能障碍性不孕（ODI）的疗效和安全性。
从 2018 年 1 月 1 日至 2023 年 3 月 12 日，系统检索了 7 个电子数据库，包括 PubMed、EMBASE、Web of Science、Cochrane Library、CNKI、万方数据库和 CBM，以识别合格的随机对照试验研究。
Meta 分析表明，与西药单独治疗相比，中药联合针灸更能有效提高性激素水平，包括老年患者的卵泡刺激素（FSH）（标准化均数差[SMD]：3.00；95%置信区间[CI]：2.35-3.66；P=0.024，I 2=28%）、年轻患者的 FSH（SMD：0.45；95%CI：-0.15，1.05；P=0.03，I 2=71%）、雌二醇（E2）（SMD：7.50；95%CI：0.47，15.48；P<0.00001，I 2=99%）和孕酮（P）（SMD：2.20；95%CI：2.07-2.33；P<0.00001，I 2=29%）。与西药单独治疗相比，中药联合针灸也能更有效地提高排卵率（风险比[RR]：2.46；95%CI：1.72-3.52；P<0.00001，I 2=0%）、妊娠率（RR：2.50；95%CI：1.96-3.18；P<0.00001，I 2=0%）、最大卵泡直径（MFD）（SMD：2.27；95%CI：1.37-3.16；P<0.00001，I 2=91%）和子宫内膜厚度（SMD：1.71；95%CI：1.31-2.11；P<0.00001，I 2=87%）。中药联合针灸还能更好地改善生活质量（RR：0.19；95%CI：0.15-0.23；P<0.00001，I 2=0%）和降低不良反应（RR：0.15；95%CI：0.05-0.48；P=0.001，I 2=0%），与西药单独治疗相比。
本研究表明，中药方剂联合针灸是一种有效且安全的治疗方法。然而，由于纳入试验的质量较低，这一结论需要进一步证实。
