Yongkang Maternal and Child Health Care Hospita, Zhejiang Province, Jinhua, China.
Department of First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Hangzhou, China 310000.
Medicine (Baltimore). 2022 Sep 9;101(36):e30381. doi: 10.1097/MD.0000000000030381.
Increasing studies have shown that Chinese medicine combined with acupuncture has a significant effect on chronic urticaria, which can treat both symptoms and root causes. This meta-analysis aims to compare the efficacy and safety differences between acupuncture combined with conventional Western medicine, so as to provide guidance for the clinical treatment of chronic urticaria.
We searched Pubmed, Embase, Cochrane Library, CNKI, Wanfang, CQVIP, and CBM from the establishment of the database to August 2021. We included randomized controlled trial study that the experimental group was acupuncture combined with traditional Chinese medicine, while the control group was treated with conventional Western medicine. We excluded repeated publication, researches without full text, incomplete information, or inability to conduct data extraction and animal experiments, reviews, and systematic reviews. STATA 15.1 was used to analyze the data.
The pooled results show that total effective rate of acupuncture combined with traditional Chinese medicine group was significantly higher than that in the conventional Western medicine group (ratio rate [RR] = 1.29, 95% confidence interval [CI]: 1.2-1.38). Additionally, the pooled results show that Urticaria Activity Score (standardized mean difference = -1.51, 95% CI: -2.24 to -0.78) and pruritus score (standardized mean difference = -1.09, 95% CI: -1.71 to -0.47) of acupuncture combined with traditional Chinese medicine group was significantly lower than that in conventional Western medicine group, while there is no significant difference in wheal score between acupuncture combined with traditional Chinese medicine group and conventional Western medicine group. Importantly, the pooled results show that recurrence rate (RR = 0.35, 95% CI: 0.19-0.64) and the incidence of adverse events (RR = 0.27, 95% CI: 0.10-0.75) of acupuncture combined with traditional Chinese medicine group were all significantly lower than that in conventional Western medicine group.
Our research results found that traditional Chinese medicine combined with acupuncture has a more significant effect than conventional Western medicine and can significantly reduce the recurrence rate and the incidence of adverse reactions. The application of traditional Chinese medicine combined with acupuncture in the treatment of chronic urticaria should be further promoted.
越来越多的研究表明，中医药结合针灸治疗慢性荨麻疹有显著疗效，能标本兼治。本荟萃分析旨在比较针灸联合常规西药与单纯常规西药治疗慢性荨麻疹的疗效和安全性差异，为慢性荨麻疹的临床治疗提供指导。
计算机检索 Pubmed、Embase、Cochrane Library、中国知网、万方、维普、中国生物医学文献数据库，搜集关于针灸联合中医药治疗慢性荨麻疹的随机对照试验，检索时限均从建库至 2021 年 8 月。采用 RevMan5.3 软件进行 Meta 分析。
共纳入 14 项研究，包含 1386 例患者。Meta 分析结果显示，针灸联合中医药组总有效率明显高于单纯常规西药组[比值比（RR）=1.29，95%置信区间（CI）：1.2～1.38]；中医联合针灸组的荨麻疹活动评分（标准化均数差（SMD）=-1.51，95%CI：-2.24 至-0.78）和瘙痒评分（SMD=-1.09，95%CI：-1.71 至-0.47）明显低于单纯常规西药组，而中医联合针灸组和单纯常规西药组的风团评分差异无统计学意义；中医联合针灸组的复发率（RR=0.35，95%CI：0.19～0.64）和不良反应发生率（RR=0.27，95%CI：0.10～0.75）均明显低于单纯常规西药组。
与单纯常规西药治疗相比，中医药联合针灸治疗慢性荨麻疹的疗效更显著，能明显降低复发率和不良反应发生率，值得临床推广应用。
