银屑病患者皮肤鸟氨酸脱羧酶活性的过度诱导。
Hyper-induction of skin ornithine decarboxylase activity in psoriatic patients.
作者信息
Bouclier M, Elbaze P, Milano G, Shroot B, Ortonne J P
出版信息
Br J Dermatol. 1986 Aug;115(2):193-8. doi: 10.1111/j.1365-2133.1986.tb05717.x.
Ornithine decarboxylase activity was measured in skin from 14 normal and 24 psoriatic subjects (with stable plaque type psoriasis vulgaris) using punch biopsies carried out immediately (0 h) and 6 h after stimulation by cellotape stripping. At 0 h, no significant difference was found between normal and involved or uninvolved psoriatic skin, but a significant increase was measured 6 h after tape stripping. This increase was significantly greater in uninvolved and involved psoriatic skin compared with normal skin. Preliminary results indicated that these changes were localized in the epidermis.
采用打孔活检法，对14名正常受试者和24名（患有稳定斑块型寻常型银屑病的）银屑病患者的皮肤进行检测，在使用胶带剥离刺激后即刻（0小时）和6小时测量鸟氨酸脱羧酶活性。在0小时时，正常皮肤与银屑病受累及未受累皮肤之间未发现显著差异，但在胶带剥离后6小时测量到显著增加。与正常皮肤相比，银屑病未受累及受累皮肤的这种增加更为显著。初步结果表明，这些变化局限于表皮。
Zotero 插件