非编码 RNA 在动脉粥样硬化中的作用：调控与治疗潜能。
Noncoding RNAs in atherosclerosis: regulation and therapeutic potential.
机构信息
Critical Care Medicine, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, 200137, Shanghai, China.
Peripheral Vascular Department, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, 300150, Tianjin, China.
出版信息
Mol Cell Biochem. 2024 May;479(5):1279-1295. doi: 10.1007/s11010-023-04794-0. Epub 2023 Jul 7.
Atherosclerosis, a chronic disease of arteries, results in high mortality worldwide as the leading cause of cardiovascular disease. The development of clinically relevant atherosclerosis involves the dysfunction of endothelial cells and vascular smooth muscle cells. A large amount of evidence indicates that noncoding RNAs, such as microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), are involved in various physiological and pathological processes. Recently, noncoding RNAs were identified as key regulators in the development of atherosclerosis, including the dysfunction of endothelial cells, and vascular smooth muscle cells and it is pertinent to understand the potential function of noncoding RNAs in atherosclerosis development. In this review, the latest available research relates to the regulatory role of noncoding RNAs in the progression of atherosclerosis and the therapeutic potential for atherosclerosis is summarized. This review aims to provide a comprehensive overview of the regulatory and interventional roles of ncRNAs in atherosclerosis and to inspire new insights for the prevention and treatment of this disease.
动脉粥样硬化是一种慢性动脉疾病，是心血管疾病的主要致死原因，在全球范围内死亡率较高。临床相关动脉粥样硬化的发展涉及内皮细胞和血管平滑肌细胞的功能障碍。大量证据表明，非编码 RNA（如 microRNAs (miRNAs)、长非编码 RNA (lncRNAs) 和环状 RNA (circRNAs)）参与各种生理和病理过程。最近，非编码 RNA 被确定为动脉粥样硬化发展的关键调节因子，包括内皮细胞和血管平滑肌细胞的功能障碍，了解非编码 RNA 在动脉粥样硬化发展中的潜在功能至关重要。在这篇综述中，总结了非编码 RNA 在动脉粥样硬化进展中的最新研究进展及其治疗潜力。本综述旨在全面概述 ncRNA 在动脉粥样硬化中的调节和干预作用，并为该疾病的预防和治疗提供新的思路。
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