山莨菪碱诱导磷脂脂质体形成六方相。
Anisodamine induces the hexagonal phase in phospholipid liposomes.
作者信息
Hwang F, Wu Y W, Wen D C
出版信息
Biochim Biophys Acta. 1986 Sep 11;860(3):713-6. doi: 10.1016/0005-2736(86)90571-7.
PMID:3741870
Abstract
The effects of anisodamine on the polymorphic phase behaviour of cardiolipin and dioleoylphosphatidylcholine liposomes have been investigated by freeze-fracture electron microscopy. Anisodamine induces the formation of lipidic particles in cardiolipin liposomes at pH 7.0 and hexagonal HII tubes at pH 8.8. When the molar ratio of anisodamine and dioleoylphosphatidylcholine is 4 to 1, lipidic particles can be observed in the fracture faces.
摘要
通过冷冻蚀刻电子显微镜研究了山莨菪碱对心磷脂和二油酰磷脂酰胆碱脂质体多晶相行为的影响。山莨菪碱在pH 7.0时诱导心磷脂脂质体中形成脂质颗粒，在pH 8.8时诱导形成六方HII管。当山莨菪碱与二油酰磷脂酰胆碱的摩尔比为4比1时，在断裂面上可观察到脂质颗粒。
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