Karaduman Aysenur, Karoglu-Eravsar Elif Tugce, Kaya Utku, Aydin Alaz, Adams Michelle M, Kafaligonul Hulusi
National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Türkiye; Interdisciplinary Neuroscience Program, Aysel Sabuncu Brain Research Center, Bilkent University, Ankara, Türkiye; Department of Molecular Biology and Genetics Zebrafish Facility, Bilkent University, Ankara, Türkiye.
Interdisciplinary Neuroscience Program, Aysel Sabuncu Brain Research Center, Bilkent University, Ankara, Türkiye; Department of Molecular Biology and Genetics Zebrafish Facility, Bilkent University, Ankara, Türkiye; National Nanotechnology Research Center (UNAM), Bilkent University, Ankara, Türkiye; Department of Psychology, Selcuk University, Konya, Türkiye.
Neurobiol Aging. 2023 Oct;130:12-21. doi: 10.1016/j.neurobiolaging.2023.06.005. Epub 2023 Jun 10.
Various aspects of visual functioning, including motion perception, change with age. Yet, there is a lack of comprehensive understanding of age-related alterations at different stages of motion processing and in each motion system. To understand the effects of aging on second-order motion processing, we investigated optomotor responses (OMR) in younger and older wild-type (AB-strain) and acetylcholinesterase (ache) mutant zebrafish. The mutant fish with decreased levels of acetylcholinesterase have been shown to have delayed age-related cognitive decline. Compared to previous results on first-order motion, we found distinct changes in OMR to second-order motion. The polarity of OMR was dependent on age, such that second-order stimulation led to mainly negative OMR in the younger group while older zebrafish had positive responses. Hence, these findings revealed an overall aging effect on the detection of second-order motion. Moreover, neither the genotype of zebrafish nor the spatial frequency of motion significantly changed the response magnitude. Our findings support the view that age-related changes in motion detection depend on the activated motion system.
视觉功能的各个方面，包括运动感知，都会随着年龄而变化。然而，目前对于运动处理不同阶段以及每个运动系统中与年龄相关的变化缺乏全面的了解。为了了解衰老对二阶运动处理的影响，我们研究了年轻和年长的野生型（AB品系）以及乙酰胆碱酯酶（ache）突变型斑马鱼的视动反应（OMR）。已证实乙酰胆碱酯酶水平降低的突变鱼与年龄相关的认知衰退延迟有关。与先前关于一阶运动的结果相比，我们发现二阶运动的OMR有明显变化。OMR的极性取决于年龄，二阶刺激在较年轻组中主要导致负向OMR，而年长的斑马鱼则有正向反应。因此，这些发现揭示了衰老对二阶运动检测的总体影响。此外，斑马鱼的基因型和运动的空间频率均未显著改变反应幅度。我们的研究结果支持这样一种观点，即与年龄相关的运动检测变化取决于激活的运动系统。
