卵巢癌中的淋巴管血管。
Lymphatic vasculature in ovarian cancer.
机构信息
Department of Medical Physiology, College of Medicine, Texas A&M University, Bryan, TX 77843, United States.
Department of Life Sciences, Presidency University, 86/1 College Street, Kolkata 700073, West Bengal, India.
出版信息
Biochim Biophys Acta Rev Cancer. 2023 Sep;1878(5):188950. doi: 10.1016/j.bbcan.2023.188950. Epub 2023 Jul 5.
Ovarian cancer (OVCA) is the second most common gynecological cancer and one of the leading causes of cancer related mortality among women. Recent studies suggest that among ovarian cancer patients at least 70% of the cases experience the involvement of lymph nodes and metastases through lymphatic vascular network. However, the impact of lymphatic system in the growth, spread and the evolution of ovarian cancer, its contribution towards the landscape of ovarian tissue resident immune cells and their metabolic responses is still a major knowledge gap. In this review first we present the epidemiological aspect of the OVCA, the lymphatic architecture of the ovary, we discuss the role of lymphatic circulation in regulation of ovarian tumor microenvironment, metabolic basis of the upregulation of lymphangiogenesis which is often observed during progression of ovarian metastasis and ascites development. Further we describe the implication of several mediators which influence both lymphatic vasculature as well as ovarian tumor microenvironment and conclude with several therapeutic strategies for targeting lymphatic vasculature in ovarian cancer progression in present day.
卵巢癌（OVCA）是第二常见的妇科癌症，也是女性癌症相关死亡的主要原因之一。最近的研究表明，在卵巢癌患者中，至少有 70%的病例通过淋巴血管网络发生淋巴结受累和转移。然而，淋巴系统在卵巢癌的生长、扩散和演变中的作用，以及它对卵巢组织固有免疫细胞景观及其代谢反应的贡献，仍然是一个主要的知识空白。在这篇综述中，我们首先介绍了 OVCA 的流行病学特征、卵巢的淋巴结构，讨论了淋巴循环在调节卵巢肿瘤微环境中的作用、在卵巢转移和腹水发展过程中经常观察到的淋巴管生成上调的代谢基础。进一步，我们描述了影响淋巴管和卵巢肿瘤微环境的几种介质的意义，并得出了几种针对卵巢癌进展中淋巴管的治疗策略。
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