高级别浆液性卵巢癌中的淋巴管血管空间侵犯与雌激素受体状态——FRANCOGYN 组的一项多中心研究。

Lymphovascular space invasion and estrogen receptor status in high-grade serous ovarian cancer - A multicenter study by the FRANCOGYN group.

机构信息

Department of Gynecology, Service de Gynécologie, Tours University Hospital, 2 Boulevard Tonnellé, Tours 37044, France.

Department of Gynecology, Service de Gynécologie, Tours University Hospital, 2 Boulevard Tonnellé, Tours 37044, France; INSERM U1069 Université François-Rabelais, Tours, France.

出版信息

J Gynecol Obstet Hum Reprod. 2022 Jan;51(1):102242. doi: 10.1016/j.jogoh.2021.102242. Epub 2021 Oct 26.

DOI:10.1016/j.jogoh.2021.102242

PMID:34715402

Abstract

BACKGROUND

The aim of this study was to evaluate the impact of Lymphovascular Space Invasion (LVSI) on Overall Survival (OS) and Recurrence-Free Survival (RFS) in patients managed for high-grade serous epithelial ovarian cancer (HGSOC).

MATERIALS AND METHODS

Retrospective multicenter study by the FRANCOGYN research group between January 2001 and December 2018. All patients managed for HGSOC and for whom histological slides for the review of LVSI were available, were included. The characteristics of patients with LVSI (LVSI group) were compared to those without LVSI (No LVSI group). A Cox analysis for OS and RFS analysis was performed in all populations.

RESULTS

Over the study period, 410 patients were included in the thirteen institutions. Among them, 289 patients had LVSI (33.9%). LVSI was an independent predictive factor for poorer Overall and Recurrence-Free Survival. LVSI affected OS (p<0.001) and RFS (p<0.001), Association of LVSI status and estrogen receptor status (ER) also affected OS and RFS (p = 0.04; p = 0.04 respectively).

CONCLUSION

The presence of LVSI in HGSOC has an impact on OS and RFS and should be routinely included in the pathology examination along with ER status.

摘要

背景

本研究旨在评估淋巴血管侵犯（LVSI）对高级别浆液性上皮性卵巢癌（HGSOC）患者总生存（OS）和无复发生存（RFS）的影响。

材料与方法

FRANCOGYN 研究组于 2001 年 1 月至 2018 年 12 月进行回顾性多中心研究。所有接受 HGSOC 治疗且有 LVSI 组织学切片可供复查的患者均被纳入研究。将有 LVSI 的患者（LVSI 组）的特征与无 LVSI 的患者（无 LVSI 组）进行比较。在所有人群中进行 COX 分析以评估 OS 和 RFS。

结果

在研究期间，13 家机构共纳入 410 名患者。其中 289 名患者有 LVSI（33.9%）。LVSI 是 OS 和 RFS 较差的独立预测因素。LVSI 影响 OS（p<0.001）和 RFS（p<0.001），LVSI 状态与雌激素受体状态（ER）的关联也影响 OS 和 RFS（p=0.04；p=0.04）。