School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin, 300384, China.
Tianjin Key Laboratory of Hazardous Waste Safety Disposal and Recycling Technology, Tianjin, 300384, China.
Environ Sci Pollut Res Int. 2023 Aug;30(37):86540-86555. doi: 10.1007/s11356-023-28592-9. Epub 2023 Jul 7.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and per- and polyfluoroalkyl substances (PFAS) are endocrine disrupting chemicals that may cause breast cancer. However, there lacks consistent research on the association between TCDD, PFAS exposure, and breast cancer. To this end, a meta-analysis was carried out in this review to explore the relationship between these two endocrine disruptors and breast cancer. Relevant literature was searched from 5 databases: Medline, Scopus, Embase, PubMed, and Web of Science. Odds ratios (OR) with 95% confidence intervals (CIs) were pooled by fixed-effects and random-effects meta-analysis models. A total of 17 publications were finally included for quantitative evaluation. Meta-analysis showed that TCDD (OR = 1.00, 95% CI = 0.89-1.12, I = 39.3%, P = 0.144), PFOA (OR = 1.07, 95% CI = 0.84-1.38, I = 85.9%, P < 0.001), PFOS (OR = 1.01, 95% CI = 0.95-1.08, I = 65.7%, P < 0.001), PFNA (OR = 0.89, 95% CI = 0.67-1.19, I = 74.4%, P < 0.001), and PFHxS (OR = 0.90, 95% CI = 0.72-1.13, I = 74%, P < 0.001) were not significantly correlated with breast cancer. Internal exposure, however, showed a significant positive correlation between TCDD and BC (OR = 2.85, 95% CI = 1.23-6.59, I = 0.0%, P = 0.882). No statistically significant association between TCDD, PFAS exposure, and breast cancer was observed in this meta-analysis.
2,3,7,8-四氯二苯并对二恶英（TCDD）和全氟及多氟烷基物质（PFAS）是内分泌干扰化学物质，可能导致乳腺癌。然而，关于 TCDD、PFAS 暴露与乳腺癌之间的关联，缺乏一致性的研究。为此，本综述进行了荟萃分析，以探讨这两种内分泌干扰物与乳腺癌之间的关系。相关文献从 5 个数据库中检索：Medline、Scopus、Embase、PubMed 和 Web of Science。采用固定效应和随机效应荟萃分析模型计算比值比（OR）及其 95%置信区间（CI）。最终共纳入 17 项定量评价研究。荟萃分析显示，TCDD（OR=1.00，95%CI=0.89-1.12，I²=39.3%，P=0.144）、PFOA（OR=1.07，95%CI=0.84-1.38，I²=85.9%，P<0.001）、PFOS（OR=1.01，95%CI=0.95-1.08，I²=65.7%，P<0.001）、PFNA（OR=0.89，95%CI=0.67-1.19，I²=74.4%，P<0.001）和 PFHxS（OR=0.90，95%CI=0.72-1.13，I²=74%，P<0.001）与乳腺癌无显著相关性。然而，内暴露显示 TCDD 与 BC 之间呈显著正相关（OR=2.85，95%CI=1.23-6.59，I²=0%，P=0.882）。本荟萃分析未观察到 TCDD、PFAS 暴露与乳腺癌之间存在统计学显著关联。
