Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Tabriz Health Services Management Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
BMC Endocr Disord. 2023 Jul 7;23(1):142. doi: 10.1186/s12902-023-01390-7.
Childhood obesity is one of the main concerns of public health. Considering its long-term adverse health effect, various studies investigated the effect of drug therapy on anthropometric parameters and provided mixed results. In this systematic review and meta-analysis, we aimed to determine the effect of Orlistat on anthropometrics and biochemical parameters in children and adolescents.
The databases of PubMed, Scopus, and Web of Science were searched until September 2022. Experimental and semi-experimental studies were included if they evaluated the effect of Orlistat on obesity-related parameters in children and reported the before and after anthropometric values. A revised Cochrane risk-of-bias (Rob2) was used to evaluate the methodological quality. STATA software version 16.0 was used for the meta-analysis of the random-effect model.
Of 810 articles retrieved in the initial search, four experimental and two semi-experimental studies were selected for systematic review. The result of the meta-analysis of experimental studies indicated the significant effect of Orlistat on waist circumference (SMD: -0.27, 95% CI: -0.47, -0.07) and serum insulin level (SMD: -0.89, 95% CI: -1.52, 0.26). However, there were no significant effects of orlistat on body weight, body mass index, lipid profile, and serum glucose level.
The present meta-analysis showed the significant effect of Orlistat on the reduction of waist circumference and insulin level in overweight and obese adolescents. However, due to the paucity of studies included in the meta-analysis, more prospective studies with longer duration and more sample sizes will be needed in this age group.
儿童肥胖是公共卫生关注的主要问题之一。鉴于其对长期健康的不良影响，各种研究都调查了药物治疗对人体测量参数的影响，但结果不一。在本次系统评价和荟萃分析中，我们旨在确定奥利司他对儿童和青少年人体测量学和生化参数的影响。
检索了 PubMed、Scopus 和 Web of Science 数据库，检索时间截至 2022 年 9 月。如果实验和半实验研究评估了奥利司他对肥胖相关参数的影响，并报告了人体测量值前后的变化，则将其纳入本研究。采用修订后的 Cochrane 偏倚风险（Rob2）评估方法学质量。采用 STATA 软件版本 16.0 对随机效应模型进行荟萃分析。
在最初的搜索中检索到 810 篇文章，其中有 4 项实验研究和 2 项半实验研究被纳入系统评价。实验研究荟萃分析的结果表明，奥利司他对腰围（SMD：-0.27，95%CI：-0.47，-0.07）和血清胰岛素水平（SMD：-0.89，95%CI：-1.52，0.26）有显著影响。然而，奥利司他对体重、体重指数、血脂谱和血清葡萄糖水平没有显著影响。
本荟萃分析表明，奥利司他对超重和肥胖青少年腰围和胰岛素水平的降低有显著作用。然而，由于纳入荟萃分析的研究较少，在该年龄段需要更多前瞻性研究，研究时间更长，样本量更大。
