S100A 家族是一组与肝癌预后不良和免疫细胞浸润相关的免疫标志物。
S100A family is a group of immune markers associated with poor prognosis and immune cell infiltration in hepatocellular carcinoma.
机构信息
Department of Hepatobiliary Surgery, Central Laboratory, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan Province, 410005, China.
Department of Cardiology, Xiangdong Hospital Affiliated to Hunan Normal University, Liling, Hunan Province, 412200, China.
出版信息
BMC Cancer. 2023 Jul 7;23(1):637. doi: 10.1186/s12885-023-11127-3.
BACKGROUND
Hepatocellular carcinoma (HCC) is one of the most common human cancers with poor prognosis in the world. HCC has become the second leading cause of cancer-related death in China. It is urgent to identify novel biomarker and valid target to effectively diagnose, treat or predict the prognosis of HCC. It has been reported that S100A family is closely related to cell proliferation and migration of different cancers. However, the values of S100As in HCC remain to be further analyzed.
METHODS
We investigated the transcriptional and translational expression of S100As, as well as the value of this family in HCC patients from the various databases.
RESULTS
S100A10 was most relevant to HCC.
CONCLUSIONS
The results from HCC patients' tissues and different cells also confirmed the role of S100A10 in HCC. Furthermore, we proved that S100A10 could influenced the cell proliferation of HCC cells via ANXA2/Akt/mTOR pathway. However, it would appear that the relationship between S100A10 and HCC is complex and requires more research.
背景
肝细胞癌（HCC）是世界上最常见的预后不良的人类癌症之一。HCC 已成为中国癌症相关死亡的第二大主要原因。迫切需要识别新的生物标志物和有效靶点，以有效诊断、治疗或预测 HCC 的预后。据报道，S100A 家族与不同癌症的细胞增殖和迁移密切相关。然而，S100As 在 HCC 中的价值仍有待进一步分析。
方法
我们从多个数据库中研究了 S100As 的转录和翻译表达，以及该家族在 HCC 患者中的价值。
结果
S100A10 与 HCC 相关性最强。
结论
来自 HCC 患者组织和不同细胞的结果也证实了 S100A10 在 HCC 中的作用。此外，我们证明 S100A10 可以通过 ANXA2/Akt/mTOR 通路影响 HCC 细胞的增殖。然而，S100A10 与 HCC 之间的关系似乎很复杂，需要进一步研究。
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