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多发性骨髓瘤伴 AL 淀粉样变性患者以孤立性肺结节为表现的淀粉瘤和浆细胞瘤:病例报告及文献复习。

Amyloidoma and Plasmacytoma Presented as a Solitary Lung Nodule in a Patient of Multiple Myeloma With AL-Amyloidosis: A Case Report and Review of Literature.

机构信息

Brookdale University Hospital Medical Center, Brooklyn, NY, USA.

State University of New York Downstate Health Sciences University, Brooklyn, USA.

出版信息

J Investig Med High Impact Case Rep. 2023 Jan-Dec;11:23247096231184768. doi: 10.1177/23247096231184768.

Abstract

Nodular amyloidoma in the lungs is a rare entity, also the occurrence of extramedullary plasmacytoma (EMP) in the lungs is rare. To have concomitant EMP and amyloidoma presented as a single lung mass is even rarer. There was only one similar case reported in the abstract form previously. Our case did not respond to many novel chemotherapy agents, suggesting that this combination of amyloidoma and plasmacytoma belonged to a poor prognosis entity, requiring different treatment modalities, such as early bone marrow transplantation or CART (chimeric antigen receptors T) therapy.

摘要

肺部结节状淀粉样变瘤是一种罕见的疾病,而肺部髓外浆细胞瘤(EMP)的发生则更为罕见。同时患有 EMP 和淀粉样变瘤并表现为单个肺部肿块的情况则更为罕见。此前仅在摘要形式中报告过一例类似病例。我们的病例对许多新型化疗药物均无反应,这表明淀粉样变瘤和浆细胞瘤的这种组合属于预后不良的实体瘤,需要采用不同的治疗方式,如早期骨髓移植或嵌合抗原受体 T 细胞(CART)治疗。

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