Dalal Bibhas Saha, Sarkar Piyabi, Maity Namrata, Nadeem Sayed Mahmood
Department of Pathology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.
Nilam Diagnostic Centre, Kolkata, West Bengal, India.
Indian J Pathol Microbiol. 2016 Oct-Dec;59(4):535-537. doi: 10.4103/0377-4929.191821.
Soft tissue amyloidoma with features similar to plasmacytoma, in absence of systemic amyloidosis, is an extremely rare finding. We hereby report the case of a 77 year old man who presented with a painless, nodular swelling on chest wall, diagnosed as soft tissue amyloidoma with plasma cell infiltration. Congo red staining was done to prove the presence of amyloid which showed characteristic "apple-green" birefringence on polarized microscopy. The plasma cells were monoclonal in origin as demonstrated by serum protein and immunofixation electrophoresis. To the best of our knowledge, this is the second such reported case. However close follow up is required, as this patient may develop multiple myeloma in future.
在无系统性淀粉样变性的情况下,具有类似于浆细胞瘤特征的软组织淀粉样瘤是一种极其罕见的发现。我们在此报告一例77岁男性病例,该患者胸壁出现无痛性结节状肿胀,诊断为伴有浆细胞浸润的软组织淀粉样瘤。进行刚果红染色以证实淀粉样物质的存在,其在偏振显微镜下显示出特征性的“苹果绿”双折射。血清蛋白和免疫固定电泳显示浆细胞起源为单克隆性。据我们所知,这是第二例此类报告病例。然而,由于该患者未来可能发展为多发性骨髓瘤,因此需要密切随访。