Turski L, Schwarz M, Klockgether T, Sontag K H
Brain Res. 1986 Aug 6;379(2):367-71. doi: 10.1016/0006-8993(86)90792-4.
Microinjection of tizanidine into the substantia nigra pars reticulata or entopeduncular nucleus reduces muscle tone in genetically spastic rats. The effect of tizanidine is related to alpha 2-adrenergic mechanism since yohimbine, an alpha 2-adrenergic antagonist, and not prazosin, an alpha 1-adrenergic antagonist, attenuates the muscle relaxation produced by the drug. These results signify basal ganglia output stations as possible sites whereby tizanidine acting via alpha 2-adrenergic mechanism exerts its muscle relaxant action.
向黑质网状部或脚内核微量注射替扎尼定可降低遗传性痉挛大鼠的肌张力。替扎尼定的作用与α2-肾上腺素能机制有关，因为α2-肾上腺素能拮抗剂育亨宾而非α1-肾上腺素能拮抗剂哌唑嗪可减弱该药物产生的肌肉松弛作用。这些结果表明，基底神经节输出站可能是替扎尼定通过α2-肾上腺素能机制发挥肌肉松弛作用的部位。
