大鼠背角中的一级伤害性感受突触被一种氨基酸拮抗剂阻断。
First-order nociceptive synapses in rat dorsal horn are blocked by an amino acid antagonist.
作者信息
Schouenborg J, Sjölund B H
出版信息
Brain Res. 1986 Aug 6;379(2):394-8. doi: 10.1016/0006-8993(86)90798-5.
PMID:3742230
Abstract
An antagonist to amino acid evoked excitation, gamma-D-glutamylglycine (gamma-DGG) inhibits, dose-dependently, nociceptive C-fibre evoked field potentials and neuronal discharges in single nociceptive neurons in rat spinal cord. It is concluded that amino acids are possible transmitter substance(s) in nociceptive afferent C-fibres. These results might be useful for development of centrally acting analgesic drugs.
摘要
γ-D-谷氨酰甘氨酸（γ-DGG）作为氨基酸诱发兴奋的拮抗剂，可剂量依赖性地抑制大鼠脊髓中单个伤害性神经元的伤害性C纤维诱发的场电位和神经元放电。得出的结论是，氨基酸可能是伤害性传入C纤维中的递质物质。这些结果可能对中枢性镇痛药的开发有用。
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