[Regulatory effect of NF-κB on prostatic hyperplasia: Progress in researches].

Benign prostatic hyperplasia (BPH) is a chronic disease, and its exact pathogenesis is not fully clear. Nuclear factor-kappa B (NF-κB), a regulatory factor that can specifically bind target genes and mediate their transcription and expression, is characterized by wide distribution and multiple functions and gradually becoming a hotspot in studies of abnormal cell proliferation-associated diseases and inflammatory diseases. Recent studies have shown that NF-κB is involved in the growth and development of hormone-dependent organs, such as the prostate, by regulating inflammatory response, disturbing endogenous hormone levels and interfering with cell apoptosis. However, few reports are seen on the relationship between NF-κB signaling pathways and BPH. This review outlines the activation of NF-κB and its regulatory pathways in BPH, expecting to provide some reference for the prevention and treatment of BPH.