College of Food Science, South China Agricultural University, Guangzhou, 510642, China.
School of Materials Science and Engineering, Dongguan University of Technology, Dongguan, 523808, China.
J Mech Behav Biomed Mater. 2023 Sep;145:105942. doi: 10.1016/j.jmbbm.2023.105942. Epub 2023 Jun 25.
The development of multifunctional and low-cost hydrogel dressings with good mechanical properties, antibacterial activity, and nontoxicity is of great relevance in healthcare. This study aimed to prepare a series of hydrogels consisting of maltodextrin (MD), polyvinyl alcohol (PVA), and tannic acid (TA) through a freeze-thaw cycling technique. Micro-acid hydrogels with different mass ratios (0, 0.25, 0.5, and 1 wt%) were obtained by adjusting the TA content. Among all hydrogels, TA-MP2 hydrogels (with a TA content of 0.5 wt%) showed good physicochemical and mechanical properties. In addition, the biocompatibility of TA-MP2 hydrogels was confirmed by the high cell survival rate of NIH3T3 cells, which was over 90% after 24 h and 48 h of incubation. Additionally, TA-MP2 hydrogels showed multifunctional properties, including antibacterial and antioxidative effects. In vivo experiments showed that TA-MP2 hydrogel dressings significantly accelerated wound healing in a full-layer skin wound model. These findings indicated the potential of TA-MP2 hydrogel dressings in promoting wound healing.
本研究旨在通过冻融循环技术制备一系列由麦芽糊精（MD）、聚乙烯醇（PVA）和鞣酸（TA）组成的水凝胶。通过调整 TA 的含量，得到了不同质量比（0、0.25、0.5 和 1wt%）的微酸性水凝胶。在所有水凝胶中，TA-MP2 水凝胶（TA 含量为 0.5wt%）表现出良好的物理化学和机械性能。此外，通过 NIH3T3 细胞的高存活率证实了 TA-MP2 水凝胶的生物相容性，孵育 24 和 48 小时后存活率均超过 90%。此外，TA-MP2 水凝胶还具有抗菌和抗氧化等多种功能。体内实验表明，TA-MP2 水凝胶敷料可显著促进全层皮肤伤口模型的伤口愈合。这些发现表明 TA-MP2 水凝胶敷料在促进伤口愈合方面具有潜力。
