School of Life Science, Xinyang Normal University, Xinyang 464000, People's Republic of China.
Tea Plant Biology Key Laboratory of Henan Province, Xinyang Normal University, Xinyang 464000, People's Republic of China.
Biomed Mater. 2024 Jan 25;19(2). doi: 10.1088/1748-605X/ad1df9.
The increased demand for improved strategies for wound healing has, in recent years, motivated the development of multifunctional hydrogels with favorable bio-compatibility and antibacterial properties. To this regard, the current study presented the design of a novel self-healing composite hydrogel that could perform as wound dressing for the promotion of wound healing. The composite hydrogels were composed of polyvinyl alcohol (PVA), borax and chitosan functionalized with sialic acid (SA-CS) and curcumin loaded pluronic F127 micelles. The hydrogels were formed through the boronic ester bond formation between PVA, SA-CS and borax under physiological conditions and demonstrated adjustable mechanical properties, gelation kinetics and antibacterial properties. When incubating with NIH3T3 cells, the hydrogels also demonstrated good biocompatibility. These aspects offer a promising foundation for their prospective applications in developing clinical materials for wound healing.
近年来，人们对改善伤口愈合策略的需求不断增加，这促使具有良好生物相容性和抗菌性能的多功能水凝胶得到了发展。有鉴于此，本研究设计了一种新型自修复复合水凝胶，可用作伤口敷料以促进伤口愈合。该复合水凝胶由聚乙烯醇（PVA）、硼砂和壳聚糖组成，其中壳聚糖经过唾液酸（SA-CS）和负载姜黄素的泊洛沙姆 F127 胶束进行了功能化修饰。在生理条件下，通过 PVA、SA-CS 和硼砂之间的硼酸酯键形成来制备水凝胶，并展示了可调的机械性能、凝胶化动力学和抗菌性能。当与 NIH3T3 细胞共孵育时，水凝胶还表现出良好的生物相容性。这些方面为其在开发用于伤口愈合的临床材料方面的潜在应用提供了有希望的基础。
