采用灵敏的气液色谱分析法对犊牛体内氯霉素进行药代动力学研究。

Pharmacokinetic study of chloramphenicol in calves using sensitive gas-liquid chromatographic analysis.

作者信息

Watson N, Black W D

出版信息

Can J Vet Res. 1986 Jul;50(3):444-6.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1255243/

Abstract

Chloramphenicol was given intravenously and intramuscularly to calves and the blood levels determined over 27 hours. At a dosage of 11 mg/kg chloramphenicol was detected in the blood for 25 hours after intravenous and 27 hours after intramuscular administration. The blood levels after intravenous administration indicate that chloramphenicol in animals moves in a two compartment model. Kinetic parameters were determined for intravenous but not intramuscular chloramphenicol treatment. The blood levels of chloramphenicol were higher following intramuscular than intravenous administration from five hours onward. Chloramphenicol distributed quickly and widely throughout the animal's body.

摘要

给小牛静脉注射和肌肉注射氯霉素，并在27小时内测定血药浓度。剂量为11mg/kg时，静脉注射后25小时和肌肉注射后27小时在血液中检测到氯霉素。静脉给药后的血药浓度表明，动物体内的氯霉素呈二室模型转运。测定了静脉注射氯霉素治疗的动力学参数，但未测定肌肉注射的。从5小时起，氯霉素的血药浓度在肌肉注射后高于静脉注射。氯霉素在动物体内分布迅速且广泛。

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引用本文的文献

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Persistence of chloramphenicol residues in calf tissues.氯霉素残留物在犊牛组织中的持久性。

Can J Vet Res. 1987 Jul;51(3):316-8.

本文引用的文献

1

Physiochemical methods for pharmacokinetic and residue analysis of chloramphenicol and degradation products in dairy cows.奶牛中氯霉素及其降解产物的药代动力学和残留分析的物理化学方法。

J Vet Pharmacol Ther. 1982 Sep;5(3):161-75. doi: 10.1111/j.1365-2885.1982.tb00427.x.

2

Pharmacokinetic study of neomycin in calves following intravenous and intramuscular administration.新霉素在犊牛静脉注射和肌肉注射后的药代动力学研究。

Can J Comp Med. 1983 Oct;47(4):433-5.

3

Pharmacokinetics of chloramphenicol in the neonatal horse.

J Vet Pharmacol Ther. 1983 Sep;6(3):219-27. doi: 10.1111/j.1365-2885.1983.tb00467.x.

4

Sensitive gas-liquid chromatographic method for chloramphenicol in animal tissues using electron-capture detection.采用电子捕获检测法测定动物组织中氯霉素的灵敏气液色谱法。

J Chromatogr. 1983 Sep 9;276(2):438-44. doi: 10.1016/s0378-4347(00)85114-2.

5

Pharmacokinetics, plasma protein binding and dosage of chloramphenicol in cattle and horses.氯霉素在牛和马体内的药代动力学、血浆蛋白结合情况及剂量

Res Vet Sci. 1973 Sep;15(2):231-8.

6

Chloramphenicol concentrations in blood and milk of cows following parenteral administration.奶牛经肠胃外给药后血液和乳汁中的氯霉素浓度。

Can Vet J. 1973 Sep;14(9):217-20.

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