Department of Laboratory Medicine, Jichi Medical University, Saitama Medical Center, 1-847 Amanuma-cho, Omiya-ku, Saitama, 330-8503, Japan.
Department of Surgery, Jichi Medical University, Saitama Medical Center, 1-847 Amanuma-cho, Omiya-ku, Saitama, 330-8503, Japan.
J Med Ultrason (2001). 2024 Oct;51(4):581-585. doi: 10.1007/s10396-023-01313-y. Epub 2023 Jul 10.
Before breast cancer surgery, sentinel lymph node (SLN) identification and biopsy using blue dye, radioisotope (RI) with a gamma probe, or a combination of the two are mainly performed. The dye-guided method requires skilled technique to make an incision in the skin and identify SLNs without damaging the lymphatic vessels. In addition, dye-induced anaphylactic shock has been reported. To use the γ-probe-guided method, the facility must be able to handle RI. However, to overcome the drawbacks of these methods, Omoto et al. developed a new identification modality using contrast-enhanced ultrasound with an ultrasound contrast agent (UCA) in 2002. Since then, many basic experiments and clinical studies using various UCA have been reported. In particular, a number of studies in SLN detection using Sonazoid have been reported and are herein reviewed.
在乳腺癌手术前，主要采用蓝染法、放射性同位素（RI）联合伽马探针或两者结合的方法进行前哨淋巴结（SLN）的定位和活检。染料引导法需要熟练的技术在不损伤淋巴管的情况下在皮肤切口内识别 SLN。此外，已报道染料诱导的过敏性休克。要使用γ 探针引导法，该设施必须能够处理 RI。然而，为了克服这些方法的缺点，大友等人于 2002 年开发了一种使用超声造影剂（UCA）增强超声的新的识别方式。此后，已经报道了许多使用各种 UCA 的基础实验和临床研究。特别是，已经报道了许多使用 SonoVue 进行 SLN 检测的研究，并在此进行了回顾。
