英国教堂墓地地衣具有某些抗菌特性的证据。
Evidence for some antimicrobial properties of English churchyard lichens.
作者信息
Taylor J A, Fourie Toscane, Powell Mark, Chianella Iva
机构信息
E.E.E.S and The Graduate School, The Open University, Walton Hall, Milton Keynes MK 7 6AA, UK.
INSERM Aix-Marseille University, Provence-Alpes-Côte d'Azur, Marseille, France.
出版信息
Access Microbiol. 2023 Jun 20;5(6). doi: 10.1099/acmi.0.000536.v4. eCollection 2023.
The emergence of multidrug-resistant bacteria has driven the need for novel antibiotics. Our investigations have focussed on lichens as they naturally produce a wide range of unique and very effective defence chemicals. The aim of this study was to evaluate some of the antimicrobial properties of ten common British churchyard lichens. The lichen material was sampled from ten species, namely , , , , subsp. , , , and . Crude acetone extracts of these lichens were tested against six bacteria ( and ) and two fungi ( and ) by the disc-diffusion susceptibility test method. Extracts of and showed clear inhibition of the Gram-positive bacteria tested (). and extracts also inhibited the dermatophyte fungi tested. The sample tested here was the only extract that showed activity against any of the Gram-negative bacteria tested; it showed inhibition of . Overall, our results showed that crude extracts of and had the most potent antimicrobial activity of all the extracts tested. Our results are in general agreement with published findings elsewhere. The activity of the margin sample being different from that of the main colony material was an interesting and new finding reported here for the first time.
多重耐药细菌的出现促使人们对新型抗生素产生需求。我们的研究聚焦于地衣，因为它们天然会产生种类繁多且极为有效的防御性化学物质。本研究的目的是评估十种常见英国墓地地衣的一些抗菌特性。地衣材料取自十个物种，即 、 、 、 亚种 、 、 、 以及 。通过纸片扩散药敏试验方法，对这些地衣的粗丙酮提取物针对六种细菌（ 和 ）和两种真菌（ 和 ）进行了测试。 和 的提取物对所测试的革兰氏阳性菌（ ）表现出明显抑制作用。 和 的提取物也抑制了所测试的皮肤癣菌。在此测试的 样本是唯一对所测试的革兰氏阴性菌表现出活性的提取物；它对 有抑制作用。总体而言，我们的结果表明，在所测试的所有提取物中， 和 的粗提取物具有最强的抗菌活性。我们的结果与其他地方发表的研究结果总体一致。 边缘样本的活性与主要菌落材料不同，这是在此首次报道的一个有趣的新发现。
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