Reduction of methicillin-resistant biofilm growth and development using arctic berry extracts.

INTRODUCTION

Surgical site infection remains a devastating and feared complication of surgery caused mainly by (). More specifically, methicillin-resistant S. aureus (MRSA) infection poses a serious threat to global health. Therefore, developing new antibacterial agents to address drug resistance are urgently needed. Compounds derived from natural berries have shown a strong antimicrobial potential.

METHODS

This study aimed to evaluate the effect of various extracts from two arctic berries, cloudberry () and raspberry (), on the development of an MRSA biofilm and as treatment on a mature MRSA biofilm. Furthermore, we evaluated the ability of two cloudberry seed-coat fractions, hydrothermal extract and ethanol extract, and the wet-milled hydrothermal extract of a raspberry press cake to inhibit and treat biofilm development in a wound-like medium. To do so, we used a model strain and two clinical strains isolated from infected patients.

RESULTS

All berry extracts prevented biofilm development of the three MRSA strains, except the raspberry press cake hydrothermal extract, which produced a diminished anti-staphylococcal effect.

DISCUSSION

The studied arctic berry extracts can be used as a treatment for a mature MRSA biofilm, however some limitations in their use exist.