Zhang Yujiao, Zhang Yong, Ren Manyi, Xue Minghua, Hu Chunying, Hou Yinglong, Li Zhiyuan, Qu Haiyan, Moreira Paulo
Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
Department of Ultrasound Diagnosis and Treatment, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
SAGE Open Med Case Rep. 2023 Jul 3;11:2050313X231179810. doi: 10.1177/2050313X231179810. eCollection 2023.
The case report shares evidence for a better understanding of atrial standstill. This being a rare arrhythmogenic condition. This is a 46-year-old woman presented with multiple sites of arterial embolism, including lower extremity arteries, coronary artery, and cerebral artery. Unexpectedly, multiple arterial embolization in the patient was due to atrial standstill by transthoracic echocardiography and cardiac electrophysiological study. An additional family investigation revealed that the patient's brother and sister also suffered from this disease. In search of further understanding the case, we carried out the genetic testing of the family and a frame shift double-G insertion mutation at c.1567 in the gene was found in all the three individuals. The patient recovered well after anticoagulation therapy and left bundle branch area pacing. This report remarks on the importance of multiple sites of arterial embolism which should be wary of family atrial standstill.
该病例报告分享了有助于更好理解心房静止的证据。这是一种罕见的致心律失常病症。这是一名46岁女性，出现多处动脉栓塞，包括下肢动脉、冠状动脉和脑动脉。经胸超声心动图和心脏电生理研究意外发现，该患者的多处动脉栓塞是由心房静止所致。进一步的家族调查显示，患者的哥哥和姐姐也患有此病。为进一步了解该病例，我们对该家族进行了基因检测，发现所有三名个体在该基因的c.1567处均存在移码双G插入突变。抗凝治疗和左束支区域起搏后，患者恢复良好。本报告指出多处动脉栓塞的重要性，应警惕家族性心房静止。
