Shandong Provincial Chronic Disease Hospital, Qingdao, China.
School of Public Health, Qingdao University, Qingdao, China.
Front Public Health. 2024 Aug 21;12:1397236. doi: 10.3389/fpubh.2024.1397236. eCollection 2024.
To ascertain the prevalence of asthma attacks among archivists and identify the associated occupational factors in this understudied professional population.
We conducted a cross-sectional, questionnaire-based study among 1,002 archival workers. A multiple logistic regression was conducted to identify the association between asthma attacks and occupational exposures. The Strobe Protocol was applied.
999 workers were included in the final analysis with the asthma prevalence of 33.3%. Main factors associated with asthma attacks (OR [95% CI]) were the presence of chemically irritating odors (2.152 [1.532-3.024]), mold odors (1.747 [1.148-2.658]), and insects (1.409[1.041-1.907]). A significant synergistic effect was observed between chemical irritants and mold, the odds ratio was 7.098 (95% CI, 4.752-10.603).
There was a high prevalence of asthma attacks among archival workers, an under-studied population. Chemical irritants, molds and insects were associated with their asthma attacks. Notably, this study's data analysis has revealed a strong synergy (OR = 7.098) between chemical odors and molds in the workplace. While the existing international literature on this specific interaction remains somewhat limited, previous studies have already demonstrated the potential for chemical irritants, such as sulfur dioxide and ozone, to synergistically interact with inhalable allergens, including fungi, molds and dust mites. Consequently, this interaction seems to exacerbate asthma symptoms and perpetuate untreated exposure. Furthermore, in damp and damaged buildings, the presence of microbial components, such as cellular debris or spores released during fungal growth can trigger an inflammatory response, potentially served as a shared pathway for the development of asthma among individuals exposed to these hazardous factors.
确定档案工作者哮喘发作的患病率，并确定该研究较少的职业人群中与哮喘发作相关的职业因素。
我们对 1002 名档案工作者进行了横断面问卷调查研究。采用多因素逻辑回归分析方法确定哮喘发作与职业暴露之间的关系。本研究按照 STROBE 指南进行。
最终纳入 999 名工人进行分析，哮喘患病率为 33.3%。与哮喘发作相关的主要因素（比值比[95%置信区间]）包括存在化学刺激性气味（2.152[1.532-3.024]）、霉菌气味（1.747[1.148-2.658]）和昆虫（1.409[1.041-1.907]）。化学刺激物和霉菌之间存在显著协同作用，比值比为 7.098（95%可信区间，4.752-10.603）。
档案工作者哮喘发作的患病率较高，这是一个研究较少的人群。化学刺激物、霉菌和昆虫与他们的哮喘发作有关。值得注意的是，本研究的数据分析显示，工作场所化学气味和霉菌之间存在强烈的协同作用（OR=7.098）。虽然关于这种特定相互作用的现有国际文献仍然有限，但以前的研究已经表明，化学刺激物，如二氧化硫和臭氧，可能与可吸入过敏原（包括真菌、霉菌和尘螨）协同作用。因此，这种相互作用似乎会加重哮喘症状，并使未经治疗的暴露持续存在。此外，在潮湿和受损的建筑物中，细胞碎片或真菌生长过程中释放的孢子等微生物成分的存在会引发炎症反应，这可能成为暴露于这些危险因素的个体发展哮喘的共同途径。
