Yao Liwei, Bu Caifang, Zhang Jinjuan, Zhang Dandan
Department of Nursing, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, China.
Department of Orthopaedics, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, China.
Front Med (Lausanne). 2023 Jun 23;10:1173368. doi: 10.3389/fmed.2023.1173368. eCollection 2023.
To evaluate the diagnostic efficacy of CapitalBio real-time polymerase chain reaction assay (CapitalBio test) in spinal tuberculosis (STB). The value of histopathology combined with the CapitalBio test in diagnosing STB was also assessed.
We retrospectively analyzed the medical information of suspected STB. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the curve (AUC) of histopathology, CapitalBio test, and histopathology combined with CapitalBio test were calculated to evaluate their diagnostic efficacy compared with a composite reference standard.
A total of 222 suspected STB patients were included in the study. The sensitivity, specificity, PPV, NPV, and AUC of histopathology for STB were recorded to be 62.0, 98.0, 97.4, 68.3%, and 0.80, respectively. The sensitivity, specificity, PPV, NPV, and AUC of the CapitalBio test were 75.2, 98.0, 97.9, 76.7%, and 0.87, respectively, while that of histopathology combined with the CapitalBio test was 81.0, 96.0, 96.1, 80.8%, and 0.89, respectively.
Histopathology and CapitalBio test exhibited high accuracy and are recommended in diagnosing STB. Histopathology combined with the CapitalBio test might give the best efficacy in STB diagnosis.
评估博奥生物实时聚合酶链反应检测法（博奥生物检测）在脊柱结核（STB）诊断中的效能。同时评估组织病理学联合博奥生物检测在诊断STB中的价值。
我们回顾性分析了疑似STB患者的医疗信息。计算组织病理学、博奥生物检测以及组织病理学联合博奥生物检测的敏感性、特异性、阳性预测值（PPV）、阴性预测值（NPV）和曲线下面积（AUC），以与综合参考标准比较来评估它们的诊断效能。
本研究共纳入222例疑似STB患者。组织病理学诊断STB的敏感性、特异性、PPV、NPV和AUC分别记录为62.0%、98.0%、97.4%、68.3%和0.80。博奥生物检测的敏感性、特异性、PPV、NPV和AUC分别为75.2%、98.0%、97.9%、76.7%和0.87，而组织病理学联合博奥生物检测的敏感性、特异性、PPV、NPV和AUC分别为81.0%、96.0%、96.1%、8
