Habib Tehmina, Abu-Abaa Mohammad, Redjal Navid
Internal Medicine, Capital Health Regional Medical Center, Trenton, USA.
Neurosurgery, Capital Health Regional Medical Center, Trenton, USA.
Cureus. 2023 Jun 8;15(6):e40115. doi: 10.7759/cureus.40115. eCollection 2023 Jun.
The association between empty sella turcica (EST) syndrome and Cushing's disease has been rarely reported. It is plausible to hypothesize that EST syndrome in association with Cushing's disease can be attributed to intracranial hypertension. In this case report, we present a 47-year-old male patient who presented with weight loss, fatigue, easy bruising, acanthosis nigricans, and skin creases hyperpigmentation. Investigations revealed hypokalemia and confirmed the diagnosis of Cushing's disease. Magnetic resonance imaging (MRI) brain showed a partial EST syndrome and a new pituitary nodule as compared with previous brain imaging. Transsphenoidal surgery was pursued and was complicated by cerebrospinal fluid leakage. This case reflects the rare association of EST syndrome and Cushing's disease, suggesting the increased risk of postoperative complications in this setting and the diagnostic challenge that EST syndrome imposes. We review the literature for a possible mechanism of this association.
空蝶鞍综合征与库欣病之间的关联鲜有报道。推测空蝶鞍综合征合并库欣病可能归因于颅内高压。在本病例报告中，我们介绍了一名47岁男性患者，其表现为体重减轻、疲劳、易出现瘀斑、黑棘皮病和皮肤皱褶色素沉着。检查发现低钾血症，并确诊为库欣病。脑部磁共振成像（MRI）显示与先前脑部影像相比存在部分空蝶鞍综合征及一个新的垂体结节。遂行经蝶窦手术，但出现了脑脊液漏的并发症。该病例反映了空蝶鞍综合征与库欣病的罕见关联，提示在此情况下术后并发症风险增加以及空蝶鞍综合征带来的诊断挑战。我们查阅文献以探寻这种关联的可能机制。
