Stratakis Constantine A
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room East 1330, CRC, 10 Center Dr. MSC1862, Bethesda, MD, 20892-1862, USA.
Rev Endocr Metab Disord. 2016 Sep;17(3):283-286. doi: 10.1007/s11154-016-9399-3.
Among the most common diagnostic manifestations of Cushing's syndrome (CS) are those involving the skin; they include violaceous striae, facial acne, hirsutism, acanthosis nigricans (AN), fungal infections, hyperpigmentation (Hp) and easy bruisability. Fortunately, most resolve within a year or two after cure of CS, although light-colored striae can persist for years depending on the age of the patients. AN, Hp, and bruisability usually resolve within months after cure in almost all ages. Facial plethora (along with acne and other facial skin changes) is a typical sign of CS that is due to increased perfusion. It resolves immediately after curative therapy of CS. Typically, the severity of the manifestations does not correlate with the biochemical indices of the disease, pointing to age, gender, genetic and skin-type differences that determine the cutaneous manifestations of CS.
库欣综合征（CS）最常见的诊断表现中包括涉及皮肤的表现；它们包括紫红色条纹、面部痤疮、多毛症、黑棘皮病（AN）、真菌感染、色素沉着（Hp）和易瘀伤性。幸运的是，大多数在CS治愈后的一两年内消退，不过浅色条纹可能会根据患者年龄持续数年。几乎在所有年龄段，AN、Hp和易瘀伤性通常在治愈后的数月内消退。面部充血（连同痤疮和其他面部皮肤变化）是CS的典型体征，这是由于灌注增加所致。它在CS的治愈性治疗后立即消退。通常，这些表现的严重程度与疾病的生化指标无关，这表明年龄、性别、遗传和皮肤类型差异决定了CS的皮肤表现。
