Chao Shing, Al-Saheli Zaid I, Zhao Wei, Ghosh Shamila, Dabak Vrushali
Internal Medicine, Henry Ford Health System, Detroit, USA.
Hematology and Oncology, Henry Ford Health System, Detroit, USA.
Cureus. 2023 Jul 5;15(7):e41427. doi: 10.7759/cureus.41427. eCollection 2023 Jul.
Hemophagocytic lymphohistiocytosis (HLH) has been rarely reported as a complication of anaplastic large cell lymphoma (ALCL), especially in the adult population. We herein present a case of a young woman who presented with multiorgan failure and disseminated intravascular hemolysis and was later found to have ALCL-associated HLH. We also review the current literature on ALCL-associated HLH in adult patients, with their respective treatments and outcomes. We discuss the challenges associated with the diagnosis of lymphoma in the setting of HLH and multiorgan failure. Further, given its high mortality rates, we highlight the importance of promptly identifying and treating the underlying etiology of HLH.
噬血细胞性淋巴组织细胞增生症（HLH）作为间变性大细胞淋巴瘤（ALCL）的一种并发症鲜有报道，尤其是在成年人群中。我们在此报告一例年轻女性病例，该患者出现多器官功能衰竭和弥散性血管内溶血，后来被发现患有与ALCL相关的HLH。我们还回顾了关于成年患者中与ALCL相关的HLH的现有文献，以及它们各自的治疗方法和结果。我们讨论了在HLH和多器官功能衰竭背景下淋巴瘤诊断所面临的挑战。此外，鉴于其高死亡率，我们强调及时识别和治疗HLH潜在病因的重要性。
