Liao Jiaxin, Li Yuting, Gui Xiaoting, Zhang Yong, Hu Xu, Cheng Liang, Hu Wen, Bai Feng
Department of Endocrinology, The Huai'an Hospital Affiliated to Xuzhou Medical University and The Second People's Hospital of Huai'an, Xuzhou Medical University, Huai'an, People's Republic of China.
Diabetes Metab Syndr Obes. 2023 Jul 3;16:2013-2024. doi: 10.2147/DMSO.S411127. eCollection 2023.
This study aimed to investigate the relationship between serum isthmin-1 (ISM1) and type 2 diabetes mellitus (T2DM), and the alteration of serum ISM1 level in both diabetic sensorimotor peripheral neuropathy (DSPN) and diabetic adults with obesity.
We recruited 180 participants (120 T2DM and 60 controls) in the cross-sectional study. First, we compared the serum ISM1 concentration in diabetic patients and non-diabetic controls. Secondly, according to DSPN, patients were divided into DSPN and non-DSPN groups. Last, patients were categorized as lean T2DM (15 males, 15 females), overweight T2DM (35 males, 19 females), and obese T2DM groups (23 males, 13 females) according to gender and body mass index (BMI). All participants were collected with clinical characteristics and biochemical profiles. Serum ISM1 was detected in all subjects by ELISA.
Higher serum ISM1 [7.78 ng/mL (IQR: 6.33-9.06) vs 5.22 (3.86-6.04), <0.001] was observed in diabetic patients compared to non-diabetic controls. Binary logistic regression analysis showed that serum ISM1 was a risk factor for type 2 diabetes after adjustment (OR=4.218, 95% CI: 1.843-9.653, =0.001). Compared to the non-DSPN group, serum ISM1 level was not changed significantly in patients who suffered from DSPN. Diabetic females with obesity had lower level of serum ISM1 (7.10±1.29 ng/mL) when compared to the lean T2DM (8.42±1.36 ng/mL, <0.05) and the overweight T2DM (8.33±1.27 ng/mL, <0.05). However, serum ISM1 was not changed significantly in male groups or all patients together.
Serum ISM1 was a risk factor for type 2 diabetes, and it was associated with diabetic adults with obesity while there was sexual dimorphism. However, serum ISM1 levels were not correlated with DSPN.
本研究旨在探讨血清峡部素-1（ISM1）与2型糖尿病（T2DM）之间的关系，以及糖尿病感觉运动性周围神经病变（DSPN）患者和肥胖糖尿病成年患者血清ISM1水平的变化。
在这项横断面研究中，我们招募了180名参与者（120名T2DM患者和60名对照）。首先，我们比较了糖尿病患者和非糖尿病对照者的血清ISM1浓度。其次，根据是否患有DSPN，将患者分为DSPN组和非DSPN组。最后，根据性别和体重指数（BMI），将患者分为瘦T2DM组（15名男性，15名女性）、超重T2DM组（35名男性，19名女性）和肥胖T2DM组（23名男性，13名女性）。收集所有参与者的临床特征和生化指标。通过酶联免疫吸附测定法（ELISA）检测所有受试者的血清ISM1。
与非糖尿病对照者相比，糖尿病患者的血清ISM1水平更高[7.78 ng/mL（四分位间距：6.33 - 9.06） vs 5.22（3.86 - 6.04），P < 0.001]。二元逻辑回归分析显示，调整后血清ISM1是2型糖尿病的一个危险因素（比值比 = 4.218，95%置信区间：1.843 - 9.653，P = 0.001）。与非DSPN组相比，患有DSPN的患者血清ISM1水平无显著变化。与瘦T2DM组（8.42±1.36 ng/mL，P < 0.05）和超重T2DM组（8.33±1.27 ng/mL，P < 0.05）相比，肥胖糖尿病女性的血清ISM1水平较低（7.10±1.29 ng/mL）。然而，男性组或所有患者的血清ISM1水平无显著变化。
血清ISM1是2型糖尿病的一个危险因素，它与肥胖糖尿病成年患者相关，且存在性别差异。然而，血清ISM1水平与DSPN无关。
