Department of Endocrinology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong University, Jinan, Shandong, China.
Department of Endocrinology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong University, Jinan, Shandong, China
BMJ Open Diabetes Res Care. 2022 Sep;10(5). doi: 10.1136/bmjdrc-2022-002972.
Isthmin-1 (Ism-1), as a novel adipokine, plays a role in glucose homeostasis and lipid metabolism. However, the relationship between Ism-1 and type 2 diabetes mellitus (T2DM) remains unclear. This study aims to investigate the association of serum Ism-1 levels with albuminuria and insulin resistance in patients with T2DM and preserved renal function.
A total of 150 patients with T2DM were recruited. The presence of albuminuria was evaluated by urinary albumin:creatinine ratio (UACR) in first morning urine sample. Serum Ism-1 levels were tested by ELISA. Homeostasis model assessments were used to evaluate insulin resistance. Binary logistic regression and multivariable linear regression analyses were used to assess the association of serum Ism-1 levels with albuminuria. Multivariable linear regression analyses were performed to explore the correlation of serum Ism-1 levels with insulin resistance.
Compared with the normal-albuminuria and microalbuminuria groups, serum Ism-1 levels were significantly higher in the macroalbuminuria group (p<0.01). Binary logistic regression analyses showed that serum Ism-1 was positively associated with odds of albuminuria even after multiple adjustments (OR=4.766, p=0.013). Serum Ism-1 was positively associated with log10-transformed UACR (β=0.625, p<0.001). However, the associations between serum Ism-1 levels and insulin resistance were not observed in patients with T2DM.
Serum Ism-1 levels were positively and independently correlated with the severity of albuminuria in patients with T2DM but not with insulin resistance.
Isthmin-1（Ism-1）作为一种新型脂肪因子，在葡萄糖稳态和脂代谢中发挥作用。然而，Ism-1 与 2 型糖尿病（T2DM）之间的关系尚不清楚。本研究旨在探讨血清 Ism-1 水平与肾功能正常的 T2DM 患者白蛋白尿和胰岛素抵抗之间的关系。
共纳入 150 例 T2DM 患者。通过晨尿中尿白蛋白与肌酐的比值（UACR）评估白蛋白尿的存在。通过 ELISA 检测血清 Ism-1 水平。使用稳态模型评估胰岛素抵抗。二元逻辑回归和多变量线性回归分析用于评估血清 Ism-1 水平与白蛋白尿之间的关系。多变量线性回归分析用于探讨血清 Ism-1 水平与胰岛素抵抗的相关性。
与正常白蛋白尿和微量白蛋白尿组相比，大量白蛋白尿组血清 Ism-1 水平显著升高（p<0.01）。二元逻辑回归分析显示，即使经过多次调整，血清 Ism-1 与白蛋白尿的发生呈正相关（OR=4.766，p=0.013）。血清 Ism-1 与经对数转换后的 UACR 呈正相关（β=0.625，p<0.001）。然而，在 T2DM 患者中，未观察到血清 Ism-1 水平与胰岛素抵抗之间存在相关性。
血清 Ism-1 水平与 T2DM 患者白蛋白尿的严重程度呈正相关且独立相关，但与胰岛素抵抗无关。
