Mattheyse F J, Engelbrecht F M
Circ Shock. 1986;19(4):385-91.
A rabbit model of hemorrhagic shock is used in assessing the use of naloxone as an adjunct in the treatment of hemorrhagic shock. In vitro oxidation rates of labelled glucose are used as parameters of early tissue damage. Naloxone, given as an adjunct to volume replacement, significantly improves the in vitro capabilities of lung and liver tissues, but has no effect on kidney cortex. Changes in MABP are not affected by naloxone in this rabbit model, and serum lysosomal enzyme activity is not significantly improved. It is proposed that naloxone exerts some of its beneficial effect at the cellular level.
使用失血性休克兔模型来评估纳洛酮作为失血性休克治疗辅助药物的效用。标记葡萄糖的体外氧化速率用作早期组织损伤的参数。纳洛酮作为容量替代的辅助药物，可显著改善肺和肝组织的体外功能，但对肾皮质无影响。在此兔模型中，平均动脉血压（MABP）的变化不受纳洛酮影响，血清溶酶体酶活性也未显著改善。有人提出，纳洛酮在细胞水平发挥其部分有益作用。
