Riddet Institute, Massey University, Private Bag 11222, Palmerston North, New Zealand.
Department of Biological and Agricultural Engineering, University of California, Davis, CA 95618, USA.
Food Funct. 2023 Jul 31;14(15):6877-6895. doi: 10.1039/d3fo00740e.
The selection of gastric digestion parameters in food digestion studies using models is critical to properly represent structural changes in the stomach. This study aimed to evaluate the performance of digestion in the human gastric simulator (HGS) using generalized gastric digestion parameters (secretion rate of 4.1 mL min, gastric emptying rate of 5.68 g min) that were derived from a previous study using six starch-rich foods. Two of the six foods used in the study (cooked durum wheat porridge/semolina and pasta) were digested in the HGS for up to 240 min, then the properties of the emptied and remaining digesta were measured. The properties of the remaining digesta were compared to those measured (growing pig stomach). The trends in the gastric breakdown rate and mechanisms, dry matter emptying kinetics, and starch hydrolysis of pasta and semolina were similar to those of . Gastric breakdown and dilution kinetics and were well-related but did not have a 1 : 1 correlation, whereas gastric acidification kinetics in the HGS deviated from that observed . The results suggest that generalized digestion parameters could be used to predict the effect of food structure on gastric breakdown and emptying, but care should be taken in interpretation of results, as the gastric acidification process was different from what was observed . This information will help refine digestion model parameters to provide more physiologically-relevant data in future studies.
使用模型进行食物消化研究中胃消化参数的选择对于正确反映胃结构变化至关重要。本研究旨在使用先前使用六种富含淀粉的食物进行的研究中得出的广义胃消化参数（分泌率为 4.1 毫升/分钟，胃排空率为 5.68 克/分钟）来评估人体胃模拟器（HGS）中的消化性能。该研究中使用的六种食物中的两种（煮熟的硬质小麦粥/粗粒小麦粉和面条）在 HGS 中消化长达 240 分钟，然后测量排空和剩余消化物的特性。剩余消化物的特性与 （生长猪胃）中测量的特性进行了比较。面条和粗粒小麦粉的胃破裂率和机制、干物质排空动力学以及淀粉水解的趋势与 相似。胃破裂和稀释动力学以及 之间存在很好的相关性，但没有 1:1 的相关性，而 HGS 中的胃酸动力学与观察到的不同。研究结果表明，广义消化参数可用于预测食物结构对胃破裂和排空的影响，但在解释结果时应谨慎，因为胃酸化过程与观察到的不同。此信息将有助于完善消化模型参数，以便在未来的研究中提供更具生理相关性的数据。
