Department of Pediatrics, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
Department of Social Pediatrics, Faculty of Medicine, Gazi University, Ankara, Turkey.
Eur J Pediatr. 2023 Sep;182(9):4123-4131. doi: 10.1007/s00431-023-05096-9. Epub 2023 Jul 10.
The frequency of vitamin D deficiency in healthy children is relatively high. Moreover, vitamin D supplementation in children is under the requested levels. The aim of this study is to determine the frequency of vitamin D deficiency and the factors that influence vitamin D levels in healthy children. During the study period, 3368 vitamin D levels of healthy children, aged 0-18 years, were evaluated retrospectively. Vitamin D levels were categorized as deficiency (< 12 ng/ml), insufficiency (12-20 ng/ml), and sufficiency (> 20 ng/ml). The prevalence of vitamin D deficiency and insufficiency was found to be 18-24.9% in healthy children, respectively. It was found that the frequency of vitamin D deficiency increased with age. In addition, the most severe and highest risk group for vitamin D deficiency were adolescent girls. Moreover, being in the winter or spring season and living in the north of the 40th parallel are the other risk factors for vitamin D deficiency.
This study showed that vitamin D deficiency still remains a major problem for healthy children and daily supplementation of vitamin D is mandatory. Prophylactic vitamin D supplementation and adequate sunlight exposure should be provided for all children, in particular healthy adolescents. In addition, future studies may focus on screening for vitamin D status in children who did not receive vitamin D supplementation.
• Vitamin D is an essential component in bone metabolism. Seasonality, age, sex, dark skin pigmentation, and limited exposure to sunlight are causes of vitamin D deficiency. • The World Health Organization has drawn attention to this increased frequency, recommending lifelong, regular vitamin D prophylaxis.
• The frequency of vitamin D deficiency and insufficiency was found to be 42.9% in healthy children and the frequency significantly increased with age. • There were almost no cases of prophylactic vitamin D usage in adolescent group which are at the highest risk.
健康儿童中维生素 D 缺乏的频率相对较高。此外,儿童的维生素 D 补充量低于要求水平。本研究旨在确定健康儿童中维生素 D 缺乏的频率以及影响维生素 D 水平的因素。在研究期间,回顾性评估了 3368 名 0-18 岁健康儿童的维生素 D 水平。将维生素 D 水平分为缺乏(<12ng/ml)、不足(12-20ng/ml)和充足(>20ng/ml)。结果发现,健康儿童中维生素 D 缺乏和不足的患病率分别为 18-24.9%。研究发现,维生素 D 缺乏的频率随年龄增长而增加。此外,维生素 D 缺乏最严重和风险最高的群体是青春期女孩。此外,冬季或春季以及居住在 40 度纬线以北是维生素 D 缺乏的其他危险因素。
本研究表明,维生素 D 缺乏仍然是健康儿童的一个主要问题,必须进行日常维生素 D 补充。应向所有儿童,特别是健康的青少年提供预防性维生素 D 补充和充足的阳光照射。此外,未来的研究可能集中在对未接受维生素 D 补充的儿童进行维生素 D 状态筛查。
• 维生素 D 是骨骼代谢的重要组成部分。季节性、年龄、性别、深色皮肤色素沉着和有限的阳光暴露是导致维生素 D 缺乏的原因。• 世界卫生组织已经注意到这种频率的增加,建议终生定期进行维生素 D 预防。
• 健康儿童中维生素 D 缺乏和不足的频率分别为 42.9%,且随着年龄的增长而显著增加。• 处于最高风险的青少年群体几乎没有预防性使用维生素 D 的情况。