成人隐匿性自身免疫性糖尿病在成年发病糖尿病患者中的全球流行率：系统评价和荟萃分析。
The worldwide prevalence of latent autoimmune diabetes of adults among adult-onset diabetic individuals: a systematic review and meta-analysis.
机构信息
Department of Human Genetics, Sri Ramachandra Institute of Higher Education and Research, Chennai, India.
Bioscience Research Foundation, Chennai, India.
出版信息
Endocrine. 2023 Oct;82(1):28-41. doi: 10.1007/s12020-023-03424-5. Epub 2023 Jul 10.
PURPOSE
The actual global burden of Latent Autoimmune Diabetes of Adults (LADA) remains unknown even though its prevalence is almost equal to the type 1 form of diabetes. Hence the present systematic review and meta-analysis were performed to estimate the prevalence of LADA among diabetic individuals using the studies published at global levels.
METHODS
A comprehensive literature revival was performed to identify articles on the prevalence of LADA published till 2023. The prevalence estimates were calculated using DerSimonian and Laird random-effects models with a heterogeneity measure by Cochrane Q and I statistics. Publication bias was assessed by the Doi plot and Luis Furuya-Kanamori asymmetry index (LFKindex). P < 0.05 was considered statistically significant.
RESULTS
The overall pooled prevalence of LADA obtained from a total of 51,725 diabetic individuals was found to be 8.9% (95%CI 7.5-10.4, P < 0.001) with a prevalence range of 2.3% in to 18.9% in United Arab Emirates and Bahrain respectively. Subgroup analysis of LADA in the context of the IDF geographic regions showed a higher prevalence in North America (13.5%), 9.5% in Middle East and North Africa, 9.4% in Africa, 9.2% in South East Asia, 8.3% in Western Pacific and the lowest prevalence of 7.0% in Europe.
CONCLUSION
The Meta-analysis revealed a worldwide prevalence of LADA as 8.9%, with the highest prevalence in Bahrain and the lowest in United Arab Emirates. Further, the higher prevalence in some IDF regions and the inconsistent association between socioeconomic status and LADA recommend more research in the future.
目的
尽管成人隐匿性自身免疫性糖尿病（LADA）的患病率几乎与 1 型糖尿病相同，但实际的全球负担仍不清楚。因此，进行了本次系统评价和荟萃分析，以使用全球范围内发表的研究来估计糖尿病患者中 LADA 的患病率。
方法
全面检索文献，以确定截至 2023 年发表的关于 LADA 患病率的文章。使用 DerSimonian 和 Laird 随机效应模型计算患病率估计值，并通过 Cochrane Q 和 I 统计量衡量异质性。通过 Doi 图和 Luis Furuya-Kanamori 不对称指数（LFKindex）评估发表偏倚。P<0.05 被认为具有统计学意义。
结果
从总共 51725 名糖尿病患者中获得的 LADA 总患病率为 8.9%（95%CI 7.5-10.4，P<0.001），患病率范围从阿联酋和巴林的 2.3%到 18.9%不等。根据 IDF 地理区域对 LADA 的亚组分析显示，北美患病率较高（13.5%），中东和北非为 9.5%，非洲为 9.4%，东南亚为 9.2%，西太平洋为 8.3%，欧洲最低为 7.0%。
结论
荟萃分析显示，全球 LADA 的患病率为 8.9%，其中巴林的患病率最高，阿联酋的患病率最低。此外，IDF 某些区域的患病率较高以及社会经济地位与 LADA 之间的不一致关联表明未来需要进行更多的研究。
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