Department of Biochemistry and Structural Biology, Lund University, Lund University, Lund, Sweden.
NanoLund, Lund University, Lund, Sweden.
Nanotoxicology. 2023 Jun;17(4):385-399. doi: 10.1080/17435390.2023.2226712. Epub 2023 Jul 10.
The attention to rare earth oxide nanoparticles (NPs), including yttrium oxide (YO), has increased in many fields due to their unique structural characteristics and functional properties. The aim of our study was to investigate the mechanisms by which bio-corona formation on YO NPs affects their environmental fate and toxicity. The YO NPs induced toxicity to freshwater filter feeder at particle concentrations of 1 and 10 mg/L, regardless of particle size. Interactions between naturally excreted biomolecules (e.g. protein, lipids, and polysaccharides) derived from and the YO NPs (30-45 nm) resulted in the formation of an eco-corona, which reduced their toxic effects toward at a particle concentration of 10 mg/L. No effects were observed at lower concentrations or for the other particle sizes investigated. Copper-zinc (Cu-Zn) superoxide dismutase, apolipophorins, and vitellogenin-1 proteins proved to be the most prominent proteins of the adsorbed corona, and possibly a reason for the reduced toxicity of the 30-45 nm YO NPs toward
由于其独特的结构特征和功能特性，人们对稀土氧化物纳米粒子（NPs），包括氧化钇（YO）的关注在许多领域都有所增加。我们的研究旨在探讨生物冠形成对 YO NPs 环境归宿和毒性的影响机制。研究结果表明，无论粒径如何，在 1 和 10mg/L 的粒子浓度下，YO NPs 对淡水滤食性动物都具有毒性。来源于 的天然排泄生物分子（如蛋白质、脂质和多糖）与 YO NPs（30-45nm）之间的相互作用导致了生态冠的形成，从而降低了它们在 10mg/L 粒子浓度下对 的毒性作用。在较低浓度或其他研究的粒径下，没有观察到这种作用。铜锌（Cu-Zn）超氧化物歧化酶、载脂蛋白和卵黄蛋白原-1 蛋白被证明是吸附冠层中最主要的蛋白质，这可能是 30-45nm YO NPs 对 的毒性降低的原因之一。
