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临床医生使用 SEER 口腔癌生存计算器要点。

Key Points for Clinicians About the SEER Oral Cancer Survival Calculator.

机构信息

VA Outcomes Group, US Department of Veterans Affairs Medical Center, White River Junction, Vermont.

Section of Otolaryngology at the Geisel School of Medicine at Dartmouth, Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, New Hampshire.

出版信息

JAMA Otolaryngol Head Neck Surg. 2023 Nov 1;149(11):1042-1046. doi: 10.1001/jamaoto.2023.1977.

Abstract

IMPORTANCE

In the setting of a new cancer diagnosis, the focus is usually on the cancer as the main threat to survival, but people may have other conditions that pose an equal or greater threat to their life than their cancer: a competing risk of death. This is especially true for patients who have cancer of the oral cavity, because prolonged exposure to alcohol and tobacco are risk factors for cancer in this location but also can result in medical conditions with the potential to shorten life expectancy, competing as a cause of death that may intervene in conjunction with or before the cancer.

OBSERVATIONS

A calculator designed for public use has been released that allows patients age 20 to 86 years who have a newly diagnosed oral cancer to obtain estimates of their health status-adjusted age, life expectancy in the absence of the cancer, and probability of surviving, dying of the cancer, or dying of other causes within 1 to 10 years after diagnosis. The models in the calculator showed that patients with oral cavity cancer had a higher than average risk of death from other causes than the matched US population, and this risk increases by stage.

CONCLUSIONS AND RELEVANCE

The Surveillance, Epidemiology and End Results Program Oral Cancer Survival Calculator supports a holistic approach to the life of the patient, and the risk of death of other causes is treated equally to consideration of the probability of death of the cancer. This tool may be usefully paired with the other available prognostic calculators for oral cancer and is an example of the possibilities now available with registry linkages to partially overlapping or independent data sets and statistical techniques that allow the use of 2 time scales in 1 analysis.

摘要

重要性

在新癌症诊断的背景下,重点通常是癌症作为对生存的主要威胁,但人们可能还有其他条件对他们的生命构成与癌症同等或更大的威胁:死亡的竞争风险。对于患有口腔癌的患者来说尤其如此,因为长期暴露于酒精和烟草是导致该部位癌症的危险因素,但也可能导致有潜在缩短预期寿命的医疗状况,作为一种死亡原因与癌症同时或之前发生竞争。

观察结果

已发布了一款供公众使用的计算器,可让 20 至 86 岁新诊断为口腔癌的患者估算其健康状况调整后的年龄、无癌症时的预期寿命以及在诊断后 1 至 10 年内生存、死于癌症或死于其他原因的概率。计算器中的模型表明,口腔癌患者死于其他原因的风险高于平均水平,且该风险随阶段增加而增加。

结论和相关性

监测、流行病学和结果计划口腔癌生存计算器支持对患者生命的整体方法,并且其他原因导致的死亡风险与考虑癌症死亡概率同等重要。该工具可能与其他可用的口腔癌预后计算器配合使用,是现在通过与部分重叠或独立数据集的登记链接以及允许在 1 次分析中使用 2 个时间尺度的统计技术实现的可能性的一个示例。

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