Various treatment modalities have been suggested for Peyronie's disease. Varying degrees of success have been reported. Certain numbers of cases will have spontaneous remission of the disease process. The treatment, however, should begin as early as possible and recognition should be achieved earlier. The injection technique utilizing a high-pressure metal syringe or syringe jacket with screw-type barrell is still the most successful for the "soft fibrosis" lesions. This was reported about twenty-five years ago. A small number of patients treated by plaque excision and full thickness skin graft replacement have also shown good results. The type of lesion present best dictates the proper treatment.