Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
Department of Pharmaceutical Technology, Faculty of Pharmacy, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.
Int J Biol Macromol. 2023 Sep 1;248:125757. doi: 10.1016/j.ijbiomac.2023.125757. Epub 2023 Jul 8.
Research and development in health care industry is in persistence progression. To make it more patient-friendly or to get maximum benefits from it, special attention to different advanced drug delivery system (ADDS) is employed that delivers the drug at the target site and will be able to sustain/control release of drugs. ADDS should be non-toxic, biodegradable, biocompatible along with desirable showing physicochemical and functional properties. These drug delivery systems can be totally based on polymers, either with natural or synthetic polymers. The molecular weight of polymer can be tuned and different groups of polymers can be modified or substituted with other functional groups. Degree of substitution is also tailored. Cationic starch in recent years is exploited in drug delivery, tissue engineering and biomedicine. Due to their abundant availability, low cost, easy chemical modification, low toxicity, biodegradability and biocompatibility, extensive research is now being carried out. Our present discussion will shed light on the usage of cationic starch in health care system.
医疗行业的研究和开发一直在持续发展。为了使医疗更贴近患者,或者从医疗中获得最大收益,人们特别关注各种先进的药物输送系统(ADDS),这种系统可以将药物输送到目标部位,并能够持续/控制药物的释放。ADDS 应该是无毒、可生物降解、生物相容的,同时具有理想的物理化学和功能特性。这些药物输送系统可以完全基于聚合物,无论是天然聚合物还是合成聚合物。聚合物的分子量可以进行调整,不同的聚合物可以用其他官能团进行修饰或取代。取代度也可以进行调整。近年来,阳离子淀粉在药物输送、组织工程和生物医学领域得到了广泛的应用。由于其丰富的可用性、低成本、易于化学修饰、低毒性、生物降解性和生物相容性,现在正在进行广泛的研究。我们目前的讨论将阐明阳离子淀粉在医疗保健系统中的应用。