School of Science, Monash University Malaysia, Bandar Sunway, Selangor Darul Ehsan, Malaysia.
Monash-Industry Palm Oil Education and Research Platform (MIPO), Monash University Malaysia, Bandar Sunway, Selangor Darul Ehsan, Malaysia.
Methods Mol Biol. 2021;2211:171-182. doi: 10.1007/978-1-0716-0943-9_12.
Polysaccharides are excellent candidates for drug delivery applications as they are available in abundance from natural sources. Polysaccharides such as starch, cellulose, lignin, chitosan, alginate, and tragacanth gum are used to make hydrogels beads. Hydrogels beads are three-dimensional, cross-linked networks of hydrophilic polymers formed in spherical shape and sized in the range of 0.5-1.0 mm of diameter. Beads are formed by various cross-linking methods such as chemical and irradiation methods. Natural polymer-based hydrogels are biocompatible and biodegradable and have inherently low immunogenicity, which makes them suitable for physiological drug delivery approaches. The cross-linked polysaccharide-based hydrogels are environment-sensitive polymers that can potentially be used for the development of "smart" delivery systems, which are capable of control release of the encapsulated drug at a targeted colon site. This topic focuses on various aspects of fabricating and optimizing the cross-linking of polysaccharides, either by a single polysaccharide or mixtures and also natural-synthetic hybrids to produce polymer-based hydrogel vehicles for colon-targeted drug delivery.
多糖是药物传递应用的优秀候选物，因为它们可以从天然来源大量获得。淀粉、纤维素、木质素、壳聚糖、藻酸盐和刺梧桐树胶等多糖被用于制造水凝胶珠。水凝胶珠是由亲水性聚合物形成的三维交联网络，呈球形，直径在 0.5-1.0 毫米范围内。珠子通过各种交联方法形成，如化学和辐射方法。基于天然聚合物的水凝胶具有生物相容性和可生物降解性，并且固有地免疫原性低，这使得它们适合生理药物传递方法。交联的基于多糖的水凝胶是环境敏感的聚合物，可潜在用于开发“智能”传递系统，该系统能够在靶向结肠部位控制封装药物的释放。本主题侧重于通过单一多糖或混合物以及天然-合成杂种来制造和优化多糖交联的各个方面，以生产用于结肠靶向药物传递的基于聚合物的水凝胶载体。
