DeGrace Sarah, Romero-Sanchiz Pablo, Yakovenko Igor, Barrett Sean P, Tibbo Philip, Cosman Tessa, Atasoy Pars, Stewart Sherry H
Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
School of Psychology, University of Sussex, Brighton, UK.
Int J Methods Psychiatr Res. 2023 Jul 10;33(1):e1979. doi: 10.1002/mpr.1979.
Derived from classical conditioning theory and rooted in motivational mechanisms, cue reactivity paradigms (CRPs) are used in addictions research to measure participants' propensities for substance-relevant responses (e.g., craving) during exposure to substance-relevant cues (e.g., drug paraphernalia). CRPs are also useful in PTSD-addiction comorbidity research, allowing the study of affective and substance-relevant responses to trauma cues. However, studies using traditional CRPs are time-consuming with high attrition rates due to repeat testing. Thus, we sought to test whether a single session semi-structured trauma interview could serve as a CRP in terms of eliciting theorized cue exposure effects on craving and affect measures.
Fifty regular cannabis users with trauma histories provided detailed descriptions of their most traumatic lifetime experience, and a neutral experience, according to an established interview protocol. Linear mixed models examined the effect of cue type (trauma vs. neutral) on affective and craving responses.
As hypothesized, the trauma interview elicited significantly greater cannabis craving (and alcohol craving among the drinkers), and, greater negative affect among those with more severe PTSD symptoms, compared to the neutral interview.
Results suggest an established semi-structured interview may function effectively as a CRP for use in trauma and addictions research.
线索反应范式(CRPs)源于经典条件作用理论,基于动机机制,在成瘾研究中用于测量参与者在接触与物质相关的线索(如吸毒用具)时对物质相关反应(如渴望)的倾向。CRPs在创伤后应激障碍(PTSD)与成瘾共病研究中也很有用,能够研究对创伤线索的情感和物质相关反应。然而,由于重复测试,使用传统CRPs的研究耗时且损耗率高。因此,我们试图测试一次半结构化创伤访谈能否作为一种CRPs,引发理论上的线索暴露对渴望和情感测量的影响。
50名有创伤史的大麻经常使用者根据既定的访谈方案,详细描述了他们一生中最具创伤性的经历以及一次中性经历。线性混合模型检验了线索类型(创伤与中性)对情感和渴望反应的影响。
如假设的那样,与中性访谈相比,创伤访谈引发了显著更强的大麻渴望(以及饮酒者中的酒精渴望),并且在PTSD症状更严重的人群中引发了更强的负面情绪。
结果表明,一种既定的半结构化访谈可能有效地作为一种CRPs用于创伤和成瘾研究。